Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Phase 1-2 18F-FPPRGD2 PET/CT or PET/MRI Imaging of αvβ3 Integrins Expression as a Biomarker of Angiogenesis
The purpose of the study is to conduct research of a new PET radiopharmaceutical in cancer patients. The uptake of the novel radiopharmaceutical 18F-FPPRGD2 will be assessed in study participants with glioblastoma multiforme (GBM), gynecological cancers, and renal cell carcinoma (RCC) who are receiving antiangiogenesis treatment.
PRIMARY OBJECTIVE
• Evaluate 18F-FPPRGD2 and 18F-FDG as PET/CT or PET/MRI radiotracers for imaging prediction
and assessment of response to anti-angiogenesis therapy in participants with glioblastoma
multiforme (GBM), gynecological cancers, and renal cell carcinoma (RCC).
SECONDARY OBJECTIVE
• Progression-free survival (PFS) at up to 1 year after initial scans and treatment
OUTLINE:
Patients undergo 18F-FPPRGD2 and 18F-FDG PET/CT or PET/MRI medical imaging at baseline and at
regular medical care follow-up (6 to 12 weeks).
After completion of study imaging, patients are followed up at 12 months.
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