Recurrent Neuroblastoma Clinical Trial
Official title:
Genetic Basis of Neuroblastoma Tumorigenesis
This laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions. Identifying genes related to cancer may help in the study of cancer. It may also help doctors predict who is at risk of developing neuroblastoma.
OBJECTIVES:
I. Perform a whole genome scan for association of neuroblastoma with single nucleotide
polymorphisms (SNP) and SNP haplotypes.
II. Identify true disease-associated SNP alleles using a customized genotyping platform
enriched for haplotype analyses in an independent sample set.
III. Validate disease-associated SNP alleles and haplotypes in a final independent sample
set.
IV. Identify neuroblastoma predisposition genes.
OUTLINE: This is a multicenter study. Participants are stratified according to presence of
high-risk disease (yes vs no) and MYCN amplification (yes vs no).
DNA samples are derived from participants' banked blood or uninvolved bone marrow. A whole
genome scan of DNA samples is employed to identify candidate single nucleotide polymorphisms
(SNPs). The candidate SNPs are investigated, using a gene-centric haplotyping approach, to
identify 10-20 true disease-associated alleles. The disease-associated alleles are again
investigated, using a gene-centric haplotyping approach, to validate 5-10 disease-associated
SNPs. SNPs are then analyzed for heritable predisposition.
Patients do not receive the results of the genetic testing. A certificate of confidentiality
protecting the identity of research participants in this project has been issued by the
Children's Oncology Group.
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