Recurrent Miscarriages Clinical Trial
Official title:
The Maternal-embryo Interaction and Its Role in the Etiology of Recurrent Miscarriages
Background of the study:
The etiology of recurrent miscarriage (RM, defined as three or more consecutive miscarriages
without any proven maternal or fetal cause), remains undiagnosed in more than 50% of cases.
In these cases it is generally considered that a disturbance in the normal mother-embryo
interactions is a causal factor. This disturbance may be based on a dysregulation of embryo
invasiveness and/or decidual acceptance (e.g. altered decidualization; endometrial changes
in preparation for the acceptance of a putative pregnancy). Moreover, dysfunctional maternal
immune regulatory natural killer (NK) cells, implicated in tolerance induction and
trophoblast invasion,may also underlie the occurrence of RM. The Selection Failure
hypothesis for RM suggests that super-receptive endometrium (possibly due to increased
embryo invasiveness and/or decidual acceptance and/or dysregulated immune cell function) may
allow 'poor quality' embryos to implant and present as a clinical pregnancy before
miscarrying. Fundamental knowledge on mechanisms of embryo implantation, decidual function
and maternal immune reactivity in successful pregnancies has accumulated over the past 5
years. This study aims to investigate whether dysregulation of (one of) these mechanisms may
underlie RM.
Objective of the study:
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness
and decidual acceptance (the quality of decidualization, endometrium-embryo communication
and endometrial stromal cell (ESC) migration) and B) the angiogenic capacity of decidual NK
(dNK) cells, in order to elucidate the pattern of the mother-embryo equilibrium in women
with RM.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02746588 -
Description of the Uterine Cavity in Patients With Recurrent Miscarriages
|
||
| Completed |
NCT00180804 -
Maternal KIR and Fetal HLA-C Genes in Recurrent Miscarriages
|