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Clinical Trial Summary

This prospective cohort study primarily aims to examine the association between blood niacin levels and recurrent miscarriage.


Clinical Trial Description

Recurrent miscarriage is affecting around 5% women at reproductive age. And the underlying causes remain undetermined in 50%-70% of cases. Although animal models and linkage analysis according to family studies have identified that niacin deficiency can lead to congenital malformations and recurrent miscarriage. Evidence based on population is lacking with regard to the effect of blood niacin levels on recurrent miscarriage. We intend to enroll 499 pregnant women confirmed by a positive blood human chorionic gonadotropin test and with history of unexplained recurrent miscarriage. By testing their blood niacin levels and following up to the end of first-trimester pregnancy, this study aims to examine the role of niacin levels in preventing miscarriages among women with history of recurrent miscarriage. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05267678
Study type Observational
Source Westlake University
Contact Hongjun Shi, PhD
Phone 86-0571-85271192
Email shihongjun@westlake.edu.cn
Status Recruiting
Phase
Start date January 28, 2023
Completion date July 1, 2024

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