Recurrent Miscarriage Clinical Trial
Official title:
Regulatory T-cell Induction by Low-dose Interleukin-2 in Women With Unexplained Repeated Spontaneous Early Miscarriages
The purpose of this study is to demonstrate the ability of low dose IL-2 to stimulate peripheral blood Tregs of women with unexplained repeated early spontaneous miscarriages for development of a therapy to prevent fetal rejection by low dose IL-2.
About 1 to 3% of women of childbearing age have repeated early spontaneous miscarriages that may be related to parental chromosomal abnormalities, uterine abnormalities, hormonal causes, infectious etiology, thrombophilia ... When one of these known causes is excluded, it is unexplained miscarriages of which half would be due to an immunological deregulation of the mother causing a decrease of the tolerance to the fetus. In this context, the stimulation of regulatory T cells (Tregs) by low dose IL-2 is a therapeutic option with a rational, preclinical and clinical data very favorable. In humans, low dose IL-2 allows preferential activation of Tregs and is very well tolerated. Several therapeutic trials have shown its efficiencies. These elements make it possible to envisage the development of a therapeutic to prevent fetal rejection by IL2-fd on the women with spontaneous miscarriages by an immunological deregulation. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT01419392 -
Role of Sildenafil Citrate in Patients With Unexplained Recurrent Miscarriages
|
Phase 4 | |
| Completed |
NCT00193674 -
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
|
Phase 3 | |
| Completed |
NCT06001060 -
Distinct Alterations in Gut Microbiota Composition Among Women of Reproductive Age With Elevated Homocysteine Levels.
|
||
| Recruiting |
NCT05034250 -
Iron Status in Female Infertility and Recurrent Miscarriage
|
||
| Completed |
NCT02681627 -
Sim (Scratch in Miscarriage) Study
|
N/A | |
| Recruiting |
NCT02303171 -
Use of Warfarin After the First Trimester in Pregnant Women With APS
|
Phase 4 | |
| Completed |
NCT02305420 -
EmbryoGen/ Blastgen for Couples With Implantation Problems or Previous Miscarriage
|
Phase 4 | |
| Recruiting |
NCT05824897 -
The Cohort Study of the Correlation Between Serum 25(OH)D Level and Pregnancy Outcome
|
||
| Completed |
NCT03023137 -
Walking and Dietary Modification for Recurrent Early Miscarriages
|
N/A | |
| Not yet recruiting |
NCT03132779 -
Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
|
Phase 1 | |
| Completed |
NCT02184741 -
A Study of the Efficacy and Safety of GB-0998 in Patients With Unexplained Recurrent Miscarriage
|
Phase 3 | |
| Active, not recruiting |
NCT02156063 -
A Multi-center, Placebo-controlled Study to Evaluate NT100 in Pregnant Women With a History of Unexplained Recurrent Pregnancy Loss (RPL)
|
Phase 2 | |
| Recruiting |
NCT03902912 -
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
|
Phase 3 | |
| Not yet recruiting |
NCT03209063 -
The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
|
||
| Not yet recruiting |
NCT06249230 -
The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk
|
||
| Recruiting |
NCT05725512 -
Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages
|
Phase 4 | |
| Recruiting |
NCT05267678 -
Nutritional Deficiency and Recurrent Miscarriage
|
||
| Completed |
NCT02504281 -
Study on the Association Between SXCI and RM and the Possible Genetic Mechanism
|
||
| Completed |
NCT02694367 -
Expression of EPK in Recurrent Miscarriage
|
N/A | |
| Completed |
NCT01608347 -
Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies
|
Phase 4 |