Recurrent Implantation Failure Clinical Trial
Official title:
PRP in Recurrent Implantation Failure , Hope or Hype
The endometrial function and endometrial receptivity have been accepted to be major limiting
factors in the establishment of pregnancy. In spite of improved almost all aspects of IVF:
ovarian stimulation, embryo culture and transfer, the pregnancy rates still not satisfactory.
The bottleneck is the process of implantation.
Recurrent implantation failure (RIF) is one of the nightmares in reproductive medicine and
despite several strategies that have been described for management; there is no universal
agreement yet.
Recently, intrauterine infusion of platelet-rich plasma (PRP) is described to promote
endometrial growth and receptivity, PRP has been investigated as a therapeutic approach for
several medical disorders in dermatology and rheumatology, but its use in IVF is still
limited.
Objective:
To evaluate the effectiveness of intrauterine perfusion of autologous platelet-rich plasma in
the improvement of pregnancy rate in RIF patients.
After ethical committee approval was obtained, 150 infertile women with history of RIF gave their written consent to be included in this study. All were recruited from the outpatient clinic of Al-Baraka fertility hospital - with age below 40 yrs, body mass index (BMI) below 30 kg/m2, whose uteri were morphologically normal as confirmed by HSG and U/S to limit additional factors that may affect the results of the study - Divided into 2 comparable groups; all participants underwent antagonist protocol, oocytes retrieval, fertilization and embryo transfer; In the study group, intrauterine infusion of 0.5 to 1 ml of platelet-rich plasma (PRP) was performed 48 hrs before blastocyst transfer, pregnancy tests were done 12 days after ET. ;
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