Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women

Status Completed

Clinical Trial Summary

The goal of this clinical trial is to investigate the influence of thyroxine supplementation on pregnancy outcomes in women with varying levels of Thyroid-Stimulating Hormone (TSH), who have experienced recurrent pregnancy loss in the first trimester. The main questions it aims to answer are: - Does thyroxine treatment improve pregnancy outcomes in women with TSH levels between 2.5 mU/L and 4 mU/L? - Is the effect of thyroxine treatment different in women with TSH levels higher than 4 mU/L? Participants will be grouped based on their TSH levels, into two groups - those with TSH levels between 2.5 mU/L and 4 mU/L, and those with TSH levels higher than 4 mU/L. They will then be given thyroxine treatment. Researchers will compare these two groups to see if the pregnancy outcomes differ based on the different TSH levels and thyroxine treatment.

Clinical Trial Description

This is a prospective clinical trial that aims to investigate the impact of thyroxine supplementation on the outcomes of pregnancies in women who have experienced recurrent pregnancy loss in the first trimester. The study will specifically focus on the role of Thyroid-Stimulating Hormone (TSH) levels in these outcomes. Participants in the study will include women who have suffered recurrent pregnancy loss in the first trimester and exhibit varying levels of TSH. For the purpose of this research, these participants will be categorized into two groups based on their TSH levels: the first group will consist of women with TSH levels between 2.5 mU/L and 4 mU/L, and the second group will include those with TSH levels higher than 4 mU/L. All participants will receive thyroxine treatment, with dosages and treatment plans as determined by their respective healthcare providers. The main purpose of this trial is to examine two key questions: Does thyroxine treatment lead to improved pregnancy outcomes in women with TSH levels between 2.5 mU/L and 4 mU/L? How does the effect of thyroxine treatment on pregnancy outcomes differ in women with TSH levels higher than 4 mU/L? The primary outcomes of interest in this study will be pregnancy success rates, defined as a viable pregnancy beyond the first trimester. Secondary outcomes might include measurements such as gestational age at delivery, birth weight, and any complications that may arise during pregnancy. This trial aims to provide valuable insights into the potential benefits of thyroxine treatment for women with varying levels of TSH who have experienced recurrent pregnancy loss. The results could contribute to the development of more effective treatment protocols and ultimately improve pregnancy outcomes for these women. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06036576
Study type	Interventional
Source	Al-Kindy College of Medicine
Contact
Status	Completed
Phase	Phase 3
Start date	March 1, 2022
Completion date	July 20, 2023

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT05975866` - The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and NFK-B in Peripheral Blood Mononuclear Cells in Patients With Hashimato	N/A
Terminated	`NCT04589884` - Intraoperative EXamination Using MAChine-learning-based HYperspectral for diagNosis & Autonomous Anatomy Assessment
Completed	`NCT00569920` - Nausea and Pain Prophylaxis During Thyroid Surgery	N/A
Recruiting	`NCT05917067` - Fluorescence Imaging of the Parathyroid Glands of Children
Completed	`NCT04704349` - Latest Imaging SPECT System Evaluation Phase 1	N/A
Recruiting	`NCT05430139` - Dried Blood Spot Testing for At Home Health
Recruiting	`NCT05635266` - Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Completed	`NCT01727973` - Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy	Phase 1/Phase 2
Recruiting	`NCT06112340` - A Phase 2b Extension Study of Two Doses of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)	Phase 2/Phase 3
Recruiting	`NCT05678374` - Exploring Immunological Markers Associated With Mental Fatigue in Graves' Disease
Not yet recruiting	`NCT04094493` - Vit D Role in Post Thyroidectomy Hypocalcemia	Early Phase 1
Completed	`NCT03157466` - Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
Completed	`NCT04542278` - Preoperative Steroids in Autoimmune Thyroid Disease	Phase 4
Completed	`NCT04425512` - Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Thyroid Malignancy	N/A
Recruiting	`NCT05510609` - Three-dimensional Ultrasonography Thyroid Volume Measurement.	N/A
Recruiting	`NCT05412680` - Transoral Endoscopic Thyroidectomy by Vestibular Approach (TOETVA)	N/A
Completed	`NCT06227819` - BVA-200 vs BVA-100 Validation Study
Completed	`NCT00150033` - Health-Related Quality of Life for Thyroid Patients	Phase 2
Active, not recruiting	`NCT04351945` - Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
Enrolling by invitation	`NCT04411290` - Malignancy Predictors, Bethesda and TI-RADS Scores Correlated With Final Histopathology in Thyroid Diseases