Chronic Myelomonocytic Leukemia Clinical Trial
Official title:
A Preliminary Study to Evaluate the Effects of Palifermin in Patients at Risk of Chronic Graft-versus-host Disease
RATIONALE: Growth factors, such as palifermin, may prevent chronic graft-versus-host disease
caused by donor stem cell transplant.
PURPOSE: This randomized clinical trial studies palifermin in preventing chronic
graft-versus-host disease in patients who have undergone donor stem cell transplant for
hematologic cancer
OBJECTIVES:
I. To evaluate the pharmacodynamic effects of palifermin on thymic function in patients at
risk of chronic graft-vs-host disease (GVHD).
II. To evaluate the tolerability of palifermin in patients at risk of chronic GVHD.
OUTLINE: Patients are assigned to 1 of 2 groups based on whether they wish to receive
palifermin or not.
GROUP 1: Patients receive palifermin intravenously (IV) on days 1-3 in the absence of
unacceptable toxicity.
GROUP 2: Patients do not receive palifermin.
After completion of study treatment, patients are followed up on days 7, 14, 21, and 28.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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