Vaccine for Patients With Newly Diagnosed or Recurrent Low-Grade Glioma

Status Completed

Clinical Trial Summary

The primary purpose of this phase II clinical trial is to determine the safety and effect on survival of patients autologous dendritic cells pulsed with autologous tumor lysate as a treatment for low-grade glioma patients. Other goals of this study are to determine if the vaccine can cause an immune response against patients' cancer cells and slow the growth of their brain tumors

Clinical Trial Description

PRIMARY OBJECTIVES: I. To determine the 5-year progression-free survival (PFS), using intradermal injections of autologous dendritic cells harvested from peripheral blood precursors and pulsed (co-cultured) with tumor lysate derived from surgical tissues in patients with low-grade gliomas. SECONDARY OBJECTIVES: I. To monitor overall survival (OS), and cellular immune responses in brain tumor patients injected with tumor lysate-pulsed dendritic cells. OUTLINE: Patients receive tumor lysate-pulsed autologous dendritic cell vaccine intradermally (ID) on days 0, 14, and 28. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01635283
Study type	Interventional
Source	Jonsson Comprehensive Cancer Center
Contact
Status	Completed
Phase	Phase 2
Start date	January 10, 2012
Completion date	May 13, 2016

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