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Rectovaginal Fistula clinical trials

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NCT ID: NCT05709717 Not yet recruiting - Perianal Fistula Clinical Trials

Regenerative Therapy With Autologous Stromal Vascular Fraction Derived Mesenchymal Stem Cells and Platelet-rich Plasma to Treat Complex Perianal Diseases

Start date: January 25, 2023
Phase:
Study type: Observational [Patient Registry]

Consecutive patients with complex anal fistula were prospectively followed for 12 months. Routine MRI was performed before and at 4 and 12 months after surgery. Continence was assessed likewise using a validated questionnaire. Fistula were drained with setons prior surgery. SVF was harvested from subcutaneous abdominal fat and PRP from peripheral blood. Distal fistulectomy to the sphincter was performed and the wound left open, while the internal orifice was closed. SVF-PRP was injected around the fistula. Patients showered their excision wound until dry. Outcomes were reported as median & interquartile range (IQR)

NCT ID: NCT05138965 Completed - Clinical trials for Healing of the Wound After Rectovaginal Fistula Surgery

the Method of Cotton Padding Promoting the Rectovaginal Fistula Surgery

Start date: January 10, 2022
Phase:
Study type: Observational

The method of Cotton Padding (mCP) was summarized by combining with many years clinical experience and the traditional ancient books.The mCP could be used in Rectovaginal Fistula (RVF) post operation effectively,in order to improve the wound.The research aim is to observe if the mCP could influence the time of staying in hospital, healing time after RVF surgery.

NCT ID: NCT05079139 Completed - Clinical trials for Obstetric Complication

Musset's Surgical Technique: Evaluation of Long-term Results (LONGOMUSSET)

LONGOMUSSET
Start date: January 20, 2022
Phase: N/A
Study type: Interventional

The surgical technique of Musset has shown its effectiveness for the cure of recto-vaginal fistulas. Recto-vaginal fistulas are mostly post-obstetric (88%). The objective of this study is to investigate the outcome of patients who underwent a Musset surgical technique, as well as their postoperative functional and anatomical results at a distance from the procedure.

NCT ID: NCT05059119 Completed - Clinical trials for Locally Advanced Cervical Cancer

Rectovaginal Fistula in Post-Radiotherapy Advanced Cervical Cancer Patients

Start date: September 1, 2020
Phase:
Study type: Observational

To investigate the associated risk factors of rectovaginal fistula

NCT ID: NCT05006586 Completed - Fistula;Rectal Clinical Trials

Rectovaginal Fistula Repair

Start date: September 15, 2020
Phase:
Study type: Observational

This study is a prospective evaluation of quality-of-life after rectovaginal fistula repair at our institution

NCT ID: NCT04940611 Active, not recruiting - Fistula Clinical Trials

A Study of Surgical Interventions in Fistulizing Conditions

Start date: August 5, 2021
Phase:
Study type: Observational

In this study, participants with complex fistulizing conditions will be treated with surgical interventions according to their clinic's standard practice. The aim of the study is to generate real-world evidence on standard of care for surgical interventions and related outcomes when treating complex fistulizing conditions. The study sponsor will not be involved in how participants are treated but will provide instructions on how the clinics will record what happens during the study.

NCT ID: NCT04519697 Recruiting - Crohn Disease Clinical Trials

Mesenchymal Stem Cells for the Treatment of Rectovaginal Fistulas in Participants With Crohn's Disease

RVF
Start date: October 28, 2020
Phase: Phase 1/Phase 2
Study type: Interventional

Approximately 10% of all female Crohn's patients have a rectovaginal fistula. Rectovaginal fistulas cause air, stool, and/or drainage per vagina and may be associated with pain, recurrent urinary tract infections and diminished quality of life. Conventional therapy includes immunosuppressive medications used to treat Crohn's disease and various surgical interventions. However, all have limited ability to heal these fistulas. The purpose of this study is to determine the safety and efficacy of using allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat people with rectovaginal fistulas in the setting of Crohn's disease.

NCT ID: NCT04267757 Completed - Clinical trials for Recto Vaginal Fistula

Transperineal Repair of Primary Obstetric Rectovaginal Fistulas

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Introduction: A rectovaginal fistula (RVF) is an epithelium-lined abnormal tract between the rectum and the vagina and is often a challenging problem for both the patients and to the surgeons. In literature, there is still debate regarding the best treatment options for rectovaginal fistulas. Aim: To assess the results of the treatment of rectovaginal fistulas with incontinence and impaired anal tonus using fistulectomy, sphincteroplasty with or without bulbocavernosus muscle (Martius) flap. Materials and Methods: A total of 22 consecutive patients with simple RVFs were included and assigned to transperineal repair. The patients were divided into two groups , group1: with Martius flap; group2: without Martius flap .Postoperatively, patients were followed up for one year at the outpatient clinic or through telephone interviews with specific questionnaires to collect information on the status of fecal control, flatus, or fecal leakage from the vagina.

NCT ID: NCT03643614 Completed - Clinical trials for Rectovaginal Fistula

Autologous Adipose-derived Regenerative Cells Injection for Treatment of Radiation-induced Rectovaginal Fistula

Start date: August 1, 2017
Phase: Phase 1
Study type: Interventional

A new strategy for treatment of late radiation damage is to develop methods aimed at stimulating the regenerative capabilities of irradiated tissues. Since the main pathogenetic mechanism of the development of late radiation damage is the death or damage of the replicative mechanism of stromal cells (SC), a justified approach can be considered as transplantation of intact SC. Currently, there is convincing evidence in the scientific literature that the injection of intact autologous SCs into the zone of fibrosis surrounding the chronic radiation ulcer leads to the healing of a wound defect. An Initiative Clinical Trial. Introduction of autologous regenerative cells of adipose tissue for the treatment of post-irradiation vaginal-rectal fistula. It is assumed that patients will be included in the project within 12 months; the monitoring of each patient will last for 6 months; the total duration of the clinical part of the study will be 18 months; The total duration of the clinical trial including the preparatory phase and the writing of the report is about 24 months. It is assumed that at least 16 patients aged 20 to 75 years who have verified diagnosis of post-irradiation vaginal-rectal fistula will participate in this pilot project. The aims of the clinical trial are to preliminarily assess the safety, effectiveness and quality of life of patients after introducing autologous regenerative cells of adipose tissue for the treatment of post-irradiation vaginal-rectal fistula.

NCT ID: NCT01548092 Recruiting - Clinical trials for Recto-vaginal Fistula

Stromal Vascular Fraction (SVF) for Treatment of Recto-vaginal Fistula

HULPCIR
Start date: December 2011
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to determine safety of Stromal Vascular Fraction (SVF) for the treatment of recto-vaginal fistula.