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Rectal Neoplasms Malignant clinical trials

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NCT ID: NCT06157463 Not yet recruiting - Clinical trials for Rectal Neoplasms Malignant

FAPI in Rectal Cancer TNT

Start date: February 15, 2024
Phase:
Study type: Observational
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NCT ID: NCT05484024 Not yet recruiting - Radiotherapy Clinical Trials

Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer

Start date: August 6, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

This phase II/III trial studies how well neoadjuvant short-course radiotherapy and chemotherapy with or without PD-1 inhibitors works in treating patients with locally advanced rectal adenocarcinoma. Neoadjuvant short-course radiation therapy followed by two-drug regimen chemotherapy, such as CAPOX, were shown to be non-inferior to standard long-course chemoradiotherapy in our previous STELLAR study. Immune checkpoint inhibitors (ICIs) using monoclonal antibodies, such as PD-1 or PD-L1 inhibitor, show promising efficiency and reliable security in some limited sample prospective or retrospective studies. When treating patients with locally advanced rectal cancer, giving sequential neoadjuvant short-course radiotherapy and chemotherapy with PD-1 inhibitor may work better.

NCT ID: NCT05067413 Enrolling by invitation - Clinical trials for Rectal Neoplasms Malignant

A Study on the Efficacy of a Novel Approach to Achieving Laparoscopic Distal Rectal Transection for Rectal Cancers

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The wide application of ISR and DST has greatly improved the anal preservation rate for low rectal cancers, but the technical difficulty has also been obviously increased because of the limited pelvic space. Although many scholars have tried to solve this problem, all the methods have failed to fundamentally solve the problem of "the oblique dissection" of the distal rectum. To solve the problem above, the director of this clinical trial has explored a new distal rectal resection method-- transanterior obturator nerve gateway approach. The purpose of this clinical trial is to prospectively collect and compare data on the patients' perioperative variables and postoperative functional and oncological outcomes of this novel approach with the traditional approach to confirm the safety and feasibility of this novel approach and its advantages over the traditional approach.

NCT ID: NCT04135313 Enrolling by invitation - Rectal Cancer Clinical Trials

Induction and Consolidation Chemotherapy in Patients With Locally Advanced CRM-positive Rectal Cancer

RuCorT-03
Start date: October 20, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether the addition of 2 cycles of induction CapOx chemotherapy and 2 cycles of consolidation CapOx chemotherapy to standard chemoradiation improves 3-year disease-free survival in patients with locally advanced CRM"+" mid and low rectal cancer.

NCT ID: NCT04134897 Enrolling by invitation - Rectal Cancer Clinical Trials

Neoadjuvant Chemotherapy in Patients With Moderate Risk Mid Rectal Cancer

RuCorT-02
Start date: October 14, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether 3 months of neoadjuvant CapOx is non-inferior to neoadjuvant radiotherapy in patients with moderate risk CRM"-" mid rectal cancer.

NCT ID: NCT04103697 Enrolling by invitation - Rectal Cancer Clinical Trials

Neoadjuvant Chemotherapy in Patients With Intermediate Risk Upper and Mid Rectal Cancer

RuCorT-01
Start date: August 1, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether 4 cycles of neoadjuvant CapOx chemotherapy is more effective than the upfront surgery in patients with intermediate risk CRM"-" mid and upper rectal cancer.

NCT ID: NCT02992886 Completed - Clinical trials for Rectal Neoplasms Malignant

Preoperative Chemoradiotherapy With Raltitrexed for Intermediate or Locally Advanced Rectal Cancer in the Fit Elderly

Start date: September 2016
Phase: Phase 2
Study type: Interventional

The aim of this multicenter phase II study is to evaluate the response rate, local control, disease-free survival and treatment-related toxicity of preoperative chemoradiation for intermediate or locally advanced rectal cancer in the fit elderly.

NCT ID: NCT02966483 Recruiting - Surgery Clinical Trials

Transanal Versus Laparoscopic Total Mesorectal Excision For Rectal Cancer

Start date: April 2016
Phase: N/A
Study type: Interventional
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