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Rectal Fistula clinical trials

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NCT ID: NCT06380036 Completed - Fistula in Ano Clinical Trials

Two Approaches to Lower the Chances of Recurrence of Anal Fistula After Surgery

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

A total of 80 patients with complex fistula in ano of both genders were included. All patients in Group A underwent a loose seton technique. In group B, video-assisted fistula tract surgery (VAAFTS) was performed.Twice daily Sitz baths, analgesics, and stool bulking agents (bran) were used in follow-up care. Repeated examinations were carried out every four weeks and recurrence was noted at the end of three months

NCT ID: NCT06314945 Completed - Perianal Fistula Clinical Trials

Diagnostic Value of Recto-perineal Ultrasound in Perianal Fistula

Start date: September 1, 2023
Phase:
Study type: Observational

Perianal fistula is a common anal problem. It needs only surgery. MRI is the best preoperative diagnostic tool, but it is demanding as it is expensive, time consuming and needs an experienced radiologist. So, we tried to find an alternative diagnostic tool which is cheaper, time saving and accurate and comparing its preoperative reports with intraoperative findings. study was held in surgery department in Zagazig University Hospitals from September 2023 to March 2024. It included 93 patients with perianal fistula who were diagnosed clinically and radiological by trans recto-perineal ultrasound and comparing pre-operative ultrasound findings with intra-operative surgical findings.

NCT ID: NCT06212739 Completed - Fistula in Ano Clinical Trials

Post-op Pain After Fistula Laser Closure or Ligation of the Intersphincteric Tract for Anal Fistula

LASERLIFT
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

This is a prospective, double-blinded randomised controlled trial conducted at two tertiary hospitals by a credentialed colorectal surgeon.

NCT ID: NCT06136325 Completed - Anal Fistula Clinical Trials

Treatment of Anal Fistulas With Obsidian RFT®

Start date: January 17, 2018
Phase:
Study type: Observational

The study conducted a retrospective analysis from January 2018 to December 2022 on patients who received anal fistula closure with Obsidian RTF® at the Department of General Surgery, Medical University of Vienna.

NCT ID: NCT05605080 Completed - Hemorrhoids Clinical Trials

Hemostatic and Analgesic Effect of Gel Foam and Gauze With Bosmin After Anal Surgery

Start date: November 7, 2022
Phase: N/A
Study type: Interventional

To evaluate the hemostatic and analgesic effect of using gauze with Bosmin or Gelfoam after anal surgery.

NCT ID: NCT05314205 Completed - Anal Fistula Clinical Trials

Ligation of Inter-sphincteric Fistula Tract for Management of Anal Fistula

Start date: January 1, 2019
Phase:
Study type: Observational

After abscess formation, an anal fistula is a common consequence, with crypto-glandular infection being the most commonly accepted causative cause. The goal of this study was to see how well closure of the inter-sphincteric fistula tract affects the outcome of trans-sphincteric fistula surgery. Patients with perianal trans-sphincteric fistulas who underwent ligation were studied prospectively. All patients had the identical anesthetic approach, followed by the operation with two years' follow-up.

NCT ID: NCT05223309 Completed - Fistula in Ano Clinical Trials

High Type Fistula in Ano, Use Staged Seton, Loose Thick Sutures

Start date: February 20, 2018
Phase:
Study type: Observational [Patient Registry]

Fistula in ano is a chronic problem for the patients. It causes distressing because of foul odor and soiling with recurrent infection and discharge. Recurrence and anal sphincter injury were the most critical complications following surgery. Loose, thick Seton placement was the most promising surgical operation. To reduce the time of Seton placement, therefore, decreasing the suffering of patients from soiling and multiple dressing.

NCT ID: NCT05201209 Completed - Clinical trials for Complex Anal Fistula

LASER FiLaCâ„¢ (FISTULA LASER CLOSURE) : First-line Treatment of Complex Anal Fistulas

Start date: February 7, 2019
Phase:
Study type: Observational

Complex anal fistula is a fistula whose treatment with fistulotomy would expose the patient to an excessive risk of post-operative continence disorders. It is a challenge in proctological surgery because of the complexity of its therapeutic management in relation to the recurrences' frequency and the need to preserve sphincter function. Indeed, management is mainly based on fistulotomy techniques, but the latter expose patients to a significant alteration of their continence (less than 10% incontinence for simple fistulas but 30-50% for complex fistulas). In addition, these fistulas' management is constraining for patients due to the need for multiple interventions, long-term post-operative care and repeated discontinuation of activity. Sphincteral saving techniques have therefore developed over the last three decades and have enriched the therapeutic panel of complex fistulas. They aim to block fistula pathways without risking altering sphincter function. In addition, their surgical consequences are often simple. However, they are associated with a greater risk of failure than after fistulotomy and sometimes disappointing to the point that some of these techniques have been gradually abandoned (biological glue and plug for example). Among these sphincteral saving techniques, the investigators know the advancement flap, the injection of biological glue, plug's installation, the LIFT (Ligation of Inter sphincteric Fistula Tract), the clip's use but also, more recently a laser treatment, FiLaCâ„¢ (for Fistula Laser Closure), knowing that the idea was not new since the ND-YAG3 and CO24.5 lasers were already used in the treatment of anal fistulas, about twenty years ago, in experimental studies. This technique consists of radiating 360° laser energy radially into the fistula path to "burn" it and causing thermal destruction by coagulation of the fistula wall ans granulation tissue2. It can bo offered to any type of fistula at risk on continence, including horseshoe extensions that can be treated at the same time. It is well suited for outpatient management because the postoperative period is simple and painless. The literature is still poor on the subject with some studies published openly but the preliminary results are encouraging with a success rate of about 70%. No continence disorders reported.

NCT ID: NCT05134168 Completed - Anal Fistula Clinical Trials

LIFT With or Without Injection of BM-MNCs

Start date: June 1, 2019
Phase: N/A
Study type: Interventional

To improve the outcome of LIFT, some authors used a combined approach of LIFT. Pooled analysis of seven studies including 192 patients revealed a success rate of 83.5 % after combined LIFT approach. The use of bone marrow aspirate concentrate (BMAC) in surgery is not entirely new as it has been widely used in the treatment of bone defects, mandibular reconstruction, maxillary sinus augmentation and in critical limb ischemia. A previous study concluded that the use of BMAC to augment external anal sphincter repair strengthens wound healing by transferring cells responsible for healing directly to the site of repair. The current study aimed to assess the outcome of local injection of bone marrow mononuclear cells (BM-MNCs) in conjunction with LIFT as compared to LIFT alone in regards to healing rate, time to healing, and ultimate success rate.

NCT ID: NCT05087407 Completed - Clinical trials for High Complex Anal Fistula

Decompression and Drainage Seton in the Treatment of High Complex Anal Fistula

Start date: December 1, 2016
Phase: N/A
Study type: Interventional

This study aimed to compare the efficacy of the decompression and drainage seton (DADS) and cutting seton (CS) in the treatment of high complex anal fistula.