Sarcoma Clinical Trial
Official title:
Evaluation of Individual Radiosensitivity of Cancer Patients to be Treated by Radiotherapy or Radiochemotherapy Per-operative
THEODORA is a prospective pilot clinical trial aiming at first to evaluate and validate the predictive value of the A & MS bioassays on tumor control by radiotherapy.
For that purpose, this project is composed of 3 stages:
- A Calibration stage that will allow to evaluate the correlation between the clinical
tumor response parameters (i.e. TV/AP features) and the radiobiological parameters
issued from the A/MS bioassays in order to develop a mathematic model defining the UTCR
parameter
- A Validation stage in order to assess the validity of A/MS bioassays towards clinical
tumour response parameters (i.e. both TV/AP features and UTCR).
- A Precision stage will be performed either to improve the precision of the predictive
performance of the A and MS bioassays or to establish a new mathematical model
describing the correlation between clinical and radiobiological parameters. The
objective of this precision stage will depend of the results of the calibration stage
(see below).
This prospective clinical study will be conducted in a population of patients with different
tumor types in order to explore a large range of tumor radiosensitivity including sarcomas,
rectal carcinoma and esophagus tumor.
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