Rectal Cancer Clinical Trial
Official title:
INTEnsification Radiotherapy With Accelerated Fractionation or ChemoTherapy And Local Excision After 3D External Radio-chemotherapy
- INTERACT study: to evaluate the pathological response rate in cT3 rectal cancer
- LEADER study: to evaluate the impact on local control of local excision
- INTERACT study: to evaluate the pathological response rate evaluated according to TRG
scale comparing accelerated radiotherapy on the gross tumour combined plus standard
radiotherapy to the pelvis in association with chronomodulated capecitabine (XELACRT
arm) versus oxaliplatin added to standard pelvis radiotherapy and same chronomodulated
Capecitabine (XELOXRT arm)
- LEADER study: to evaluate the impact on local control of local excision in patients who
had a major clinical response evaluated by MRI and confirmed by TRG 1-2 score.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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