Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage

Recovery Clinical Trial

Official title:

Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05220371
• Other study ID #: 00765
• Status: Completed
• Phase: N/A
• Start date: January 28, 2022
• Est. completion date: June 30, 2023

Study information

• Verified date: August 2023
• Source: University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: June 30, 2023
• Est. primary completion date: June 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• No subjective symptoms during physical exertion

• Stable weight and dietary behaviour

• Body Mass Index (BMI) between 18.5 and 24.9

• No extensive strength/endurance sports so far (less than 3 h/week)

• No complaints during strenuous physical activity

Exclusion Criteria:

• Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)

• Intolerance/aversion to animal protein

• Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest

• Presence of insulin-dependent diabetes mellitus

• Liver and/or kidney disease that precludes a high protein load

• Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Related Conditions & MeSH terms

• Recovery

Intervention

Dietary Supplement:
• Collagen
Participants ingest 15 grams of either specific collagen peptides or Placebo daily

Other:
• Concurrent training
Both arms undergo a 12-week trainingintervention 3x/week

Locations

Country	Name	City	State
Austria	University of Vienna, Institute of Sport Science	Vienna

Sponsors (2)

Lead Sponsor	Collaborator
University of Vienna	CRI Collagen Research Institute GmbH

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in maximal voluntary contraction (MVC)	Measured by isokinetic dynamometer	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Primary	Change in rate of force development (RFD)	Measured by isokinetic dynamometer	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Primary	Change in countermovement jump height (CMJ)	Measured by force plate	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Primary	Change in subjective pain score	Measured by visual analogue scale	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Primary	Change in Achilles tendon cross-sectional area	Measured by ultrasound	Baseline and after 12 weeks
Primary	Change in Vastus Lateralis fibre length	Measured by ultrasound	Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Primary	Change in collagen related blood markers	Measured by blood analysis	Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Primary	Change in Achilles tendon echo intensity	Measured by ultrasound	Baseline and after 12 weeks
Primary	Change in Vastus Lateralis echo intensity	Measured by ultrasound	Baseline and after 12 weeks
Primary	Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)	Measured by bioelectrical impedance analysis	Baseline and after 12 weeks