Recovery From Anesthesia Clinical Trial
Official title:
The Effect of Preoperative Aminophylline on the Recovery Profile After Major Pelvi-abdominal Surgeries: Randomized Controlled Double Blinded Study
Several clinical studies and case reports suggested that aminophylline antagonizes the effects of diazepam , barbiturates , sevoflurane ,morphineand propofol.However, the available results from uncontrolled clinical settings make it difficult to quantify the specific effects of aminophylline on hypnotics and anesthetics
Aminophylline, a theophylline derivative, exerts multiple pharmacological effects, either
through phosphodiesterase inhibition (i.e., a potent bronchodilating action, which is often
used for the treatment of bronchial asthma) or via adenosine receptor blockade .It is
generally considered that the majority of actions ascribed to therapeutic doses of xanthines
(caffeine and theophylline) are due to their action as adenosine receptor antagonists.
To the best of the investigator's knowledge this hypothesis was not reported in patients
scheduled for major pelvi-abdominal surgeries under general anesthesia , and aminophylline
was not given as premedication to test this hypothesis as it was previously administrated
after the end of surgery ,also it was recommended by previous clinical studies to evaluate
the effective dose of aminophylline that affect the extubation and recovery time.
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