Reaction Time Clinical Trial
Official title:
Individualized Focused Ultrasound Stimulation of the Brain to Enhance Alertness and Cognitive Performance
The investigators goal is to target FUS energy to the centromedian nucleus of the thalamus (CMT), the core of arousal, which is inaccessible by traditional non-invasive neuromodulation devices. The CMT is an ideal stimulation target for augmenting alertness, as it is intimately linked with the cortex through the well described thalamocortical circuit to entrain network oscillations.
In this research study, the investigators will utilize a novel wearable device (ATTN201) to test the dose-response effects of FUS stimulation of the centromedian nucleus of the thalamus (CMT) on alertness, cognitive performance, and reaction time, as well as sleep EEG recordings. Unlike existing technologies, the device in this study will use offline MRI guidance, which is not needed during the actual treatment, allowing users for the first time to sleep and comfortably wear the device out of the clinic. This unique offline MRI guidance approach uses the device's precise head registration and brain anatomy to allow for customized and repeatable tFUS delivery to the CMT. For this study, the investigators will recruit up to 36 healthy subjects for a safety study that will objectively assess brain parenchyma morphology, and neuropsychiatric and neuropsychological function, following tFUS exposure of the CMT. EEG recordings during parametric sweeps will be obtained for observation of changes in brain network activity. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05926050 -
The Acute Effects of a Dietary Supplement on Cognitive Performance in Highly Trained Athletes.
|
N/A | |
| Completed |
NCT05998096 -
A Randomized Study to Examine the Ability of a Caffeine-Based Energy Drink to Impact Energy Expenditure, Fat Oxidation, Reaction Time, and Other Perceptual Indicators
|
N/A | |
| Completed |
NCT03439930 -
The Effect of Balance Training on Neuromuscular Control in Subjects With CAI
|
N/A | |
| Completed |
NCT01972581 -
Neurocognitive Visual Reaction Training
|
N/A | |
| Completed |
NCT05839743 -
Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, Balance, Fall Risk, Reaction Time, Cognitive Functions and Quality of Life in Dementia Patients
|
N/A | |
| Completed |
NCT01592175 -
Magnetoencephalography (MEG), Attention and Conscience
|
||
| Completed |
NCT03903250 -
Effects of A-GPC on Reaction Time and Cognitive Function
|
N/A | |
| Completed |
NCT04859153 -
Relevant Factors on Sprint Performance in Adolescent Sprinters
|
||
| Completed |
NCT02203539 -
The Influence of Light Exposure on Exercise Performance Dependent on Chronotype.
|
N/A | |
| Completed |
NCT06168747 -
Reaction Time After Mobilization
|
N/A | |
| Completed |
NCT04060238 -
Effect of Protanopia on the Brightness Perception of Brake Lights
|
||
| Recruiting |
NCT06308731 -
Exercise-Induced Rates of Fat Oxidation With and Without Ingestion of a Caffeine-Based Energy Drink
|
N/A | |
| Not yet recruiting |
NCT05472727 -
Comparison of Physical Fitness, Walking Speed, Reaction Time In Older Adults With and Without Mild Cognitive Impairment
|