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Clinical Trial Summary

Patients with metastatic non small cell lung cancer with high risk location or size are treated with prophylactic radiation therapy in conjunction with standard of care systemic therapy.


Clinical Trial Description

This will be a single-cohort Phase II single center, prospective trial. Patients with stage IV NSCLC are eligible. Patients may receive standard of care systemic therapy (chemotherapy and/or immunotherapy). Radiotherapy will be directed at high-risk disease (primary cancer, nodal metastases, and metastases) in the thorax. Treatment of other sites of extrathoracic metastases would be allowed as per standard of care. Standard chest radiation dosing and normal tissue exposures (based on published or ongoing studies) will be applied. There is no plan to escalate the chest radiation dose (i.e., no Phase I component) as palliative regimens for NSCLC have been routinely used for many decades. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06262321
Study type Interventional
Source University of Rochester
Contact Therese Smudzin
Phone 585-275-7848
Email Therese_Smudzin@urmc.rochester.edu
Status Recruiting
Phase Phase 2
Start date May 15, 2024
Completion date February 1, 2029

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