Glioblastoma Multiforme Clinical Trial
Official title:
(18F)-Fluoroethyl-L-tyrosine Positron Emission Tomography and Multiparametric MRI for the Delination of Target Volumes in High-grade Glioma Patients Undergoing Radiotherapy
Glioblastoma is the most common malignant brain tumor in adults. The primary treatment
consists of maximal tumor removal followed by radiotherapy (RT) with concomitant and adjuvant
temozolomide. Tumor recurrence after chemoradiotherapy has previously been shown to be
predominantly within or at the margin of the irradiated volume, but distant failure are not
rare, especially in patients with MGMT methylation.Traditionally, RT has been planned based
on on planning CT with co-registered postoperative MRI, with the addition of a clinical
target volume margin of 2-3 cm to account for infiltrative odema.
To better characterize the disease, more specific physiological and/or metabolical markers of
tumor cells, vascularization and hypoxia measured on multiparametric MRI as perfusion,
diffusion and spectroscopy alongside with PET tracer like Fluoroéthyl-L-tyrosine ([18F]-FET)
are now available and suggest that aggressive areas, like uptake of PET tracer and
vascularity are present outside areas of contrast enhancement usually irradiated. These
informations could be incorporated to optimize the treatment of radiotherapy.
n/a
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