ATM Variants in Radiotherapy Patients

Radiotherapy Clinical Trial

Official title:

ATM Variants in Radiotherapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00214227
• Other study ID #: RO05305
• Secondary ID: 2005-0122A533300
• Status: Completed
• Start date: December 2007
• Est. completion date: January 2013

Study information

• Verified date: June 2013
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to compare the baseline incidence of variant alleles in the ATM and/or other DNA repair genes present in the Native American population versus the non-Native American population. It is thought that a higher baseline incidence of the variant alleles in the ATM gene may correlate to higher rates and higher grades of radiation toxicities noted in the Native American population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: January 2013
• Est. primary completion date: January 2013
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Indication for radiotherapy.

• Ability or desire to donate a blood sample and be followed closely for radiation toxicities

Related Conditions & MeSH terms

• Radiotherapy

Locations

Country	Name	City	State
United States	University of Wisconsin Hospital and Clinics	Madison	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	to determine baseline incidence of variant alleles in ATM	to determine the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy	one blood draw
Secondary	to compare the baseline incidence of variant alleles in ATM	to compare the baseline incidence of variant alleles in ATM resent in the population of Native americans with cancer who are undergoing radiation therapy to a similar group of non-native americans who have undergone or are undergoing raditohterapy	one blood draw

External Links

•   University of Wisconsin Carbone Cancer Center