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Clinical Trial Summary

To observe the efficacy and toxicities of post-operative (R0/R1) proton radiotherapy for locally advanced primary thymus epithelial malignancies. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was overall survival and cause-specific survival.


Clinical Trial Description

Patients who received R0 resection will receive 45GyE per 18 fractions proton irradiation. Patients who received R1 resection will receive 50GyE per 20 fractions proton irradiation. Patients with thymus cancer should receive combined platinum based chemotherapy (including etoposide combined with cisplatin / carboplatin / loplatin / nedaplatin, paclitaxel combined with cisplatin / carboplatin / loplatin / nedaplatin, Docetaxel combined with cisplatin / carboplatin / loplatin / nedaplatin) for at least 4 cycles. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was overall survival and cause-specific survival. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06311968
Study type Interventional
Source Shanghai Proton and Heavy Ion Center
Contact Jing Li
Phone 86-21-38296678
Email jing.li@sphic.org.cn
Status Recruiting
Phase Phase 2
Start date April 1, 2024
Completion date February 28, 2027

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