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Clinical Trial Summary

This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal melanoma with iodine-125 plaque brachytherapy.


Clinical Trial Description

The primary objectives are to compare long-term visual acuity outcomes in eyes that receive repeated treatment with faricimab or fluocinolone acetonide intravitreal implants with those observed initially and treated only if macular edema (ME) develops. The secondary objectives are to determine if repeated treatment with faricimab or fluocinolone acetonide intravitreal implants versus observation can prevent or alter the course of ME from radiation retinopathy and to evaluate the natural history of radiation retinopathy with multimodal imaging including widefield color photographs, widefield fluorescein angiography and OCTA. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05844982
Study type Interventional
Source Jaeb Center for Health Research
Contact Cynthia Stockdale, MPH
Phone 8139758690
Email DRCRNET@JAEB.ORG
Status Recruiting
Phase Phase 3
Start date November 21, 2023
Completion date November 26, 2028

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