Enhancement and Restoring of Low Dose Abdominal CT Images

Radiation Protection Clinical Trial

Official title:

Enhancement and Restoring of Low Dose Abdominal CT Images by a Novel Adaptive Nonlinear 3D Post Processing Filter - a Prospective Blinded Interventional Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01059032
• Other study ID #: 15017044793
• Status: Completed
• Phase: Phase 1
• First received: January 21, 2010
• Last updated: June 1, 2015
• Start date: December 2009
• Est. completion date: December 2011

Study information

• Verified date: November 2009
• Source: University of Oslo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Norwegian Social Science Data Services
• Study type: Interventional

Clinical Trial Summary

Through the rapid growth of multislice Computer Tomography (CT) imaging, radiation protection has become a major issue in the radiological community. Optimizing CT scanning is a key task when keeping the radiation doses as low as reasonable achievable (the ALARA principle). Post processing filters can improve and restore grainy and noisy low dose CT images by enhancing structure and reducing image noise. In our study of 10 patients, the investigators perform a preliminary evaluation of a novel post processing filter, which does picture element correlations in all three spatial dimensions. By comparing normal dose pictures with unprocessed low-dose pictures and pictures processed with two dimentional (2D) and three dimentional (3D) filters,the investigators will be able to assess the possible clinical value of the 3D filter. This project is collaboration between Buskerud Hospital (BU), Buskerud University College, Norwegian Radiation Protection Authority (NRPA) and Center for Medical Image Science and Visualization (CMIV). The project is part of the PhD of Lars Borgen.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2011
• Est. primary completion date: December 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 60 Years to 90 Years

Eligibility

Inclusion Criteria:

• Outpatients, Male or female,Age above 60 years, Referred to our department for an abdominal CT with intravenous contrast.

Exclusion Criteria:

• Abdominal diameter less than 80cm or larger than 100cm, Gross pancreatic pathology, Gross anatomic anomalies in the investigated region, Intolerance of intravenous contrast

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Radiation Protection

Intervention

Other:
• Using a 3 dimentional post processing filter
Using a 3 dimentional post processing filter

Locations

Country	Name	City	State
Norway	Buskerud Hospital	Drammen

Sponsors (2)

Lead Sponsor	Collaborator
Lars Borgen	Sykehuset Buskerud HF

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rating of image quality		3-6 months	No