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The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis

Gut Microbiota Clinical Trial

Official title:
The Effects of Bifidobacterium and Lactobacillus Tablets Combined With Compound Glutamine in the Prevention and Treatment of Radiation Proctitis.

Clinical Trial Summary

Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can significantly relieve the symptoms of radiation proctitis through preliminary clinical practice, but the mechanism is unknown. Through a prospective randomized controlled study, this study intends to investigate the incidence of grade 2 or higher acute radiation proctitis in patients of locally advanced rectal cancer after radiotherapy with the combined therapy. And through various scales, next-generation sequencing methods and other methods to evaluate the clinical symptoms, colonoscopy, imaging, and changes in the species and abundance of intestinal flora before and after treatment. To further explore the related pathways and mechanisms affecting radiation proctitis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05406882
Study type Interventional
Source West China Hospital
Contact xin wang, PhD/MD
Phone +86 28 85423609
Email wangxin213@sina.com
Status Recruiting
Phase Phase 2/Phase 3
Start date April 15, 2022
Completion date September 30, 2024
View Details
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