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Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis

Radiation Pneumonitis Clinical Trial

Official title:
Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis

Clinical Trial Summary

To verify the efficacy and safety of endostatin in the treatment of SRILI（symptomatic radiation-induced lung injury） and fibrosis. The results of this study are expected to be a new clinical strategy for the treatment of radiation pneumonia and fibrosis.

Clinical Trial Description

Radiotherapy is an important treatment of lung cancer, symptomatic radiation-induced lung injury (SRILR) is the most common complications. In view of the important role of endostatin in inhibiting angiogenesis and pro-inflammatory factors, Combined with randomized controlled clinical study and small sample clinical exploration, the investigators concluded that endostatin is a new clinical technique for the treatment of radiation pneumonia（RP） and radiation fibrosis（RF）, which can reduce the recurrence rate of RP. In order to verify the efficacy and safety of endostatin in the treatment of SRILI and fibrosis, the investigators intend to use a prospective, randomized, multicenter clinical trial to classify unresectable phase III-IV Non-small cell lung cancer（NSCLC） patients with SRILI above grade 2 into the control group (standard SRILI treatment) and observation group (Endostar® plus standard treatment) on a 1:1 randomized basis. The results of this study are expected to be a new clinical strategy for the treatment of radiation pneumonia and fibrosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03796364
Study type Interventional
Source Xinqiao Hospital of Chongqing
Contact
Status Completed
Phase Phase 2
Start date September 1, 2018
Completion date July 31, 2020
View Details
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