Radiation Injury Clinical Trial
Official title:
Effect of Cardiac Computed Tomography Angiography on the Blood Reactive Oxygen Species Level
The clinically widely used X-ray computed tomography examination has a low-grade radiation
effect and recently has attracted much attention concerning the possible adverse effects of
radiation on human body [ref. 1-5]. The radiation is harmful to human tissues and cells
mainly because it can interact with water (which makes up to 80% of cells) to generate
reactive oxygen species (ROS), especially the formation of hydroxyl radicals. So far as we
can reach, there is no report concerning the relation between X-ray computed tomography
examination and the blood ROS level. Therefore, we wish to conduct this study to clarify if
the cardiac computed tomography angiography (cardiac CTA) may induce a higher level of ROS
in the peripheral blood.
Study subjects will be OPD patients who are arranged for cardiac CTA examination because of
suspect coronary artery disease (CAD). In total, twenty cases will be enrolled for the
study. The formal consent will be delivered and explained to the patients and families after
the arrangement of cardiac CTA. It then will be retrieved just before the performance of
cardiac CTA.
For each enrolled case, peripheral blood will be sampled three times (once before and twice
after the performance of cardiac CTA). Totally 60 blood samples will be collected from 20
study subjects within 3 months (January 1 ~ March 31, 2009). ROS level in the collected
blood samples will be then measured, compared, and analyzed.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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