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Radiation-Induced Mucositis clinical trials

View clinical trials related to Radiation-Induced Mucositis.

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NCT ID: NCT06307327 Recruiting - Clinical trials for Head and Neck Cancer

Comparative Study of New Classification and Traditional Classification of Radioactive Oropharyngeal Mucositis

Start date: March 2024
Phase:
Study type: Observational

Radiation oropharyngeal mucositis is one of the most painful side effects of radiotherapy in patients with head and neck tumors. However, the traditional radioactive oropharyngeal mucositis grading system has the problem of poor evaluation consistency. To solve this problem, we innovatively classify radiation oropharyngeal mucositis into four types according to the four-stage histopathological changes of acute radiation injury: (1) congestive; (2) Scattered erosion type; (3) Fusion erosion type; (4) Ulcer type. We intend to conduct a multicenter observational cohort study to compare the consistency of different physicians in the assessment of radiation oropharyngeal mucositis with new and traditional classifications, and to explore changes in blood markers of different types of oropharyngeal mucositis using clinical residual blood samples.

NCT ID: NCT05982197 Completed - Clinical trials for Head and Neck Cancer

Curcumin Gel On Radiation Induced Oral Mucositis

Start date: January 3, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a relationship between the curcumin clinical effect and production of EGFs and IL8. Researchers will compare between curcumin group and standard treatment group.

NCT ID: NCT05856188 Recruiting - Clinical trials for Radiation-Induced Mucositis

Efficacy of Glutamine in Management of Radiation Mucositis

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

The goal of this [ type of study: Clinical trial] is to test effectiveness of glutamine in management of Radiation Induced Mucositis in head and neck cancer patients. The main question [s] ] is to [ learn about, test, compare etc.] it aims to answer are: 1. Is glutamine effective in management of Radiation Induced Mucositis? 2. Does Glutamine oral suspension affect the level of TGFβ1 in saliva of patients with radiation induced mucositis? participants will be asked to dissolve oral glutamine and maltodextrin in distalled water and swish and swallow three times daily during radiotherapy.

NCT ID: NCT05757479 Recruiting - Clinical trials for Radiation-Induced Mucositis

Steroid-Eluting Stent Implant for the Treatment of Radiation-Related Sinusitis

Start date: February 11, 2023
Phase: Phase 3
Study type: Interventional

Sinusitis is one of the most common sequelae after radiotherapy among nasopharyngeal carcinoma patients. While local steroids have been shown to be effective in the management of patients with chronic rhinosinusitis, their role in treating radiation-related sinusitis is ambiguous. Poor adherence to nasal steroid spray often contributes to the failure of symptom relief. The aim of this study is to determine if steroids stents implantation into the sinuses could improve patient outcomes in radiation-related sinusitis.

NCT ID: NCT05721885 Not yet recruiting - Clinical trials for Head and Neck Cancer

Effect of Nutritional Management on RIOM in Patients With Advanced Head and Neck Cancer

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to learn about the effect of nutritional management on radiation-induced oral mucositis in patients with advanced head and neck cancer during the peri-radiotherapy period . The main questions it aims to answer are: - [question 1]Whether whole-course nutritional intervention can improve radiation-induced oral mucositis in patients with HNC. - [question 2]Whether whole-course nutritional intervention can improve nutritional status and inflammation. Participants will be treated according to the NCCN guidelines. In addition, clinical pharmacists and registered dietitians provided nutritional intervention strategies based on clinical and nutritional assessments for the patients in the peri-radiotherapy nutrition group. Researchers will compare clinical routine examination and nutritional indicators between the standard treatment group and the peri-radiotherapy nutrition management group to see if nutrition management effects.

NCT ID: NCT05322421 Recruiting - Clinical trials for Oral Mucositis (Ulcerative) Due to Radiation

Effectiveness of Topical Olive Oil in Prevention and Management of Radiation Induced Oral Mucositis

Start date: January 10, 2022
Phase: N/A
Study type: Interventional

This research aims to investigate the effectiveness of topical olive oil application both clinically and biochemically as a suitable affordable treatment modality for prevention and management of radiation oral mucositis and its associated pain for head and neck cancer patients receiving radiotherapy.

NCT ID: NCT05055726 Completed - Clinical trials for Head and Neck Cancer

Benzydamine Oromucosal Solution in Oral Mucositis (BOOM)

BOOM
Start date: December 6, 2021
Phase: Phase 4
Study type: Interventional

The aim of the present study is to collect data on the feasibility of a preventative/therapeutic approach of radiation-induced oral mucositis with benzydamine oromucosal solution (mouthwash) in patients with head and neck cancer.

NCT ID: NCT05023863 Not yet recruiting - Clinical trials for Radiation-Induced Mucositis

The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients

Start date: September 1, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

A prospective, randomized, controlled, single-blinded study will be conducted at Clinical Oncology department, Ain Shams University Hospitals, assessing the effect of Alpha Lipoic Acid on the incidence and severity of radiotherapy induced oral mucositis in Head and Neck cancer patients.

NCT ID: NCT04221165 Completed - Clinical trials for Head and Neck Cancer

Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer

Start date: August 4, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the daily pain level scores for patients taking opioids alone for pain relief, compared with those treated by multimodal analgesia with three medications: pregabalin, naproxen, and acetaminophen, with the ability to switch over to opioid medications if needed. In addition to pain level scores, this study will compare opioid use (length of time and doses taken), quality of life, admissions to hospital, feeding tube requirements, weight loss, and treatment interruptions between these two analgesic regimens.

NCT ID: NCT03359187 Completed - Clinical trials for Head and Neck Cancer

Prevention of Mucositis in Patients With Head and Neck Cancer Treated With Radiotherapy

Start date: February 2016
Phase: N/A
Study type: Interventional

Prevention of radiation-induced mucositis in patients with head and neck cancer treated with radiotherapy : A Double-blind Randomized Controlled Trial