Radiation Fibrosis Clinical Trial
Official title:
A Pilot Study Of Pirfenidone For The Treatment Of Radiation-Induced Fibrosis
RATIONALE: Pirfenidone may prevent or lessen fibrosis caused by radiation therapy.
PURPOSE: Pilot trial to study the effectiveness of pirfenidone in preventing or lessening
fibrosis in patients who have undergone radiation therapy for cancer.
OBJECTIVES:
- Determine the safety and therapeutic efficacy of pirfenidone in cancer patients with
radiation-induced fibrosis.
OUTLINE: Patients receive oral pirfenidone 3 times daily. Treatment continues for up to 2
years in the absence of disease progression or unacceptable toxicity.
Principal functional abilities are assessed at baseline, every 3 months, and at termination
of therapy.
PROJECTED ACCRUAL: A total of 10-25 patients will be accrued for this study within 1 year.
;
Primary Purpose: Supportive Care
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