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RAD51B Gene Mutation clinical trials

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NCT ID: NCT06392841 Not yet recruiting - BRCA2 Gene Mutation Clinical Trials

Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations

HARMONY
Start date: December 2024
Phase: Phase 2
Study type: Interventional

This is an open label, phase II trial in subjects with treatment naïve, metastatic hormone sensitive prostate cancer (mHSPC) with deleterious homologous recombination repair (HRR) alteration(s). These include pathologic alterations in BRCA 1/2, BRIP1, CHEK2, FANCA, PALB2, RAD51B, and/or RAD54L. A total of 64 people will be enrolled to the study.