Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load

Quadriceps Muscle Clinical Trial

Official title:

Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03950596
• Other study ID #: HYMC-58-16
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 2019
• Est. completion date: May 2020

Study information

• Verified date: May 2019
• Source: Hillel Yaffe Medical Center
• Contact: Eias Kassem, MD
• Phone: 972-50-6246882
• Email: eiask[@]hy.health.gov.il
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 300
• Est. completion date: May 2020
• Est. primary completion date: May 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Non-professional athletes

• Pass heart/lung endurance tests

• Pass ergometrics testing

Exclusion Criteria:

• Have been injured

• Had physiotherapy for back or lower limbs in past 6 months

• Orthopedic surgery in lower limbs

Related Conditions & MeSH terms

• Quadriceps Muscle

Intervention

Other:
• Acute resistant load exercises
Leg bench and leg press acute resistant load exercises Leg-bench and leg-press acute resistant load exercises

Behavioral:
• Background Questionnaire
Background questionnaire will be filled out by participants

Other:
• Pain Questionnaire
Pain questionnaire regarding pain in the knee during previous 3 months

Genetic:
• DNA and RNA test
DNA and RNA tests will be sent to a genetic laboratory for analysis

Diagnostic Test:
• Ultrasound
Ultrasound of the knee joint and the quadriceps muscle and the pica tendon
• Percutaneous Needle Core Biopsy
Core Biopsy will be taken from the quadriceps femoris muscle

Locations

Country	Name	City	State
Israel	Hillel Yaffe Medical Center	Hadera

Sponsors (1)

Lead Sponsor	Collaborator
Hillel Yaffe Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Genetic Changes in Knee Muscle and Tendon	Comparison of results of genetic testing both before and after interventions between the 3 groups	One year
Primary	Ultrasound Changes in Knee Muscle and Tendon	Comparison of results of pre- and post ultrasound changes after interventions between the 3 groups	One year
Primary	Biopsy Changes in Knee Muscle and Tendon	Comparison of changes in biopsies taken before and after interventions between the 3 groups	One year