QTc-interval Clinical Trial
Official title:
Influence of Cortisone on QTc-interval
Scientific and clinical data report about shortening of QTc-interval in patients treated with
cortisone. Peal et al. analyzed chemical suppression of long QT syndrome (Type 2) in an in
vivo zebrafish model. Their study revealed that flurandrenolide reproducibly suppressed the
long QT phenotype via the glucocorticoid signaling pathway. In contrast to treatment with
dexamethasone and testosterone, treatment with pure mineralocorticoid deoxycorticosterone
acetate did not suppress long QT phenotype. Knockdown of the glucocorticoid receptor or,
conversely, of the androgen receptor showed that flurandrenolide acting through the
glucocorticoid receptor shortens ventricular action potentials. The mechanism is distinct
from trafficking rescue of the defective zebrafish-ERG channel. The authors discuss that a
drug normalizing repolarization would be a novel therapeutic tool in long QT syndrome and
conclude that glucocorticoids could be expected to aid in the acute management of patients
with long QT syndrome, e.g. in episodes of arrhythmic storm. In addition, corticoid induced
normalization of the QT interval is reported in a patient with drug-induced prolongation of
the QTc interval. Brostoff et al. report on a patient suffering from mucocutaneous
leishmaniasis treated with sodium stibogluconate. During therapy, the QTc interval prolonged
and returned to normal within 4 days after starting glucocorticoid therapy with prednisolone
20 mg twice daily.
Interrogation of the study:
- shortens cortisone the QTc-interval?
- how long is the interval until shortening of QTc-interval?
- is the effect prolonged?
- is the effect dose dependend?
n/a