Pyelonephritis Clinical Trial
Official title:
Study of the Effect of Acetylcysteine on Inflammation Biomarkers in Pediatric Acute Pyelonephritis.
In different studies, it has been shown that "antioxidant" utilization has favorable
therapeutic effects not only on control of acute symptoms but also on prevention of delayed
problems from acute and chronic pyelonephritis.
According to the efficacy of acetylcysteine as a potent antioxidant, safety of this drug and
side effects of similar or either less than placebo, this study was designed to evaluate the
efficacy of this drug on inflammatory biomarkers of pediatric acute pyelonephritis. It is a
triple-blind placebo controlled study on a population of 64 patients 1-16 years old that
have "definite" or "probable" diagnosis of acute pyelonephritis in "Mofid" hospital.
After randomization, patients will be given acetylcysteine or placebo with dosing according
to their weight. Results of treatment are evaluated according to serum procalcitonin, C
reactive protein and leukocyte count before drug prescription (baseline) and 5 days after
drug prescription. Side effects are also recorded in both groups. Patients will be receiving
their routine antimicrobial drugs in addition to acetylcysteine.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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