Pulpitis Clinical Trial
Official title:
Effect of Celebrex Pre-medication on the Intra and Post-treatment Endodontic Pain in Teeth With Symptomatic Irreversible Pulpitis: Double Blind Randomized Clinical Trial
Assessing the efficacy of Celebrex premedication on pain during and after endodontic treatment in teeth with symptomatic irreversible pulpits
Owing to the painful nature of endodotnic treatment in teeth with irreversible pulpits,
administration of an analgesic and anti-inflammatory could help to lessen the perception of
pain, hence decreasing the patient apprehension.
Previous clinical trials have shown that the use of NSAIDS as a premedication prior to
endodontic treatment was effective in reducing the pain and increasing the anesthetic
success, since as high as 80% of the patients with pre-operative pain experience pain after
endodontic treatment.
In this study, Celebrex (Celecoxib) 200mg will be given to the patients 1 hour before
initiation of the treatment, and its effect on reducing the pain will be compared with a
placebo.
Celebrex being a selective COX-2 inhibitor, it will spare the physiological tissue
prostaglandin production while inhibiting the inflammatory prostaglandin production thus
allow for effective analgesia with fewer side effects than Non-Selective NSAIDS (nsNSAIDS).
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