Tissue Characterization in Teeth Treated With a Regeneration Protocol

Status Completed

Clinical Trial Summary

The purpose of the investigators study is to characterize the composition of the hard and soft tissues present in root canals of teeth previously diagnosed with necrotic pulps and incomplete root formation and treated with a triple antibiotic regeneration protocol. The investigators hypothesis is that treatment of teeth with necrotic pulps and immature apices with triple antibiotic paste will stimulate continued root formation by the deposition of dentin at the root apices. The primary outcome measure will be histological identification of mineralized tissue and adherent cells in the apical third of these teeth.

Clinical Trial Description

'Regeneration' as referred to in this protocol refers to the stimulation of continued root formation by the deposition of apical tissues subsequent to disinfection of a necrotic root canal and its contents and creation of a scaffold upon which cells can proliferate. While the proposed treatment protocol is currently being used in clinical practice and has been shown to be successful in case reports and case series, the nature of the proliferating apical tissues remains unknown. Thus, this study is uniquely positioned to address a critical gap in knowledge in the regeneration of a functional pulp-dentin complex. Moreover, results obtained from pediatric cases may well provide the essential foundation of knowledge for endodontists to apply this knowledge to the more difficult situation of regenerating the pulp-dentin complex of the full mature permanent tooth. ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00881907
Study type	Interventional
Source	The University of Texas Health Science Center at San Antonio
Contact
Status	Completed
Phase	Phase 0
Start date	March 2010
Completion date	March 2014

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See also
Status	Clinical Trial	Phase
Completed	`NCT01976065` - Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots	Phase 1
Active, not recruiting	`NCT03763110` - Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth	N/A
Recruiting	`NCT04313010` - Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis	N/A
Not yet recruiting	`NCT03813433` - Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth	N/A
Completed	`NCT03589560` - Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth	N/A
Not yet recruiting	`NCT03717337` - Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth	N/A
Completed	`NCT01817413` - Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma	Phase 4
Completed	`NCT03849222` - Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth	Phase 2/Phase 3
Completed	`NCT00881491` - Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste	Phase 0