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Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

Pulp Necrosis Clinical Trial

Official title:
Treatment Outcome With a Revascularization Protocol Using the Triple Versus Double Antibiotic Paste

Clinical Trial Summary

The purpose of this study is to determine the treatment outcomes in permanent teeth with necrotic pulp and immature root development that undergo a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline) versus a double antibiotic paste (ciprofloxacin, metronidazole)compared to the commonly used mineral trioxide aggregate (MTA) apexification treatment.

Clinical Trial Description

Recent case series have reported positive outcomes treating necrotic immature permanent teeth with a regenerative procedure using a triple antibiotic paste (ciprofloxacin, metronidazole, minocycline). However, this method can result in considerable staining due to minocycline. In this randomized clinical trial, we will compare clinical outcomes of a triple antibiotic paste versus a double antibiotic paste (ciprofloxacin, metronidazole) intracanal medicament as compared to a standard treatment (immediate apexification with MTA) in permanent teeth with necrotic pulps and immature root development. We hypothesize there will be no significant differences between radiographic measures of root development after treatment with either the double versus triple antibiotic paste, and that both methods will produce significantly greater increases in root length and width compared to standard treatment. The primary outcome measures will be radiographic measurement of root length and dentinal wall thickness and the secondary outcomes will be lack of clinical symptoms and crown staining. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00881491
Study type Interventional
Source The University of Texas Health Science Center at San Antonio
Contact
Status Completed
Phase Phase 0
Start date April 2009
Completion date January 2015
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See also
  Status Clinical Trial Phase
Completed NCT01976065 - Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots Phase 1
Active, not recruiting NCT03763110 - Photo-Activated Disinfection Versus Triple-Antibiotic Paste for Management of Necrotic Young Permanent Anterior Teeth N/A
Completed NCT00881907 - Tissue Characterization in Teeth Treated With a Regeneration Protocol Phase 0
Recruiting NCT04313010 - Effectiveness of Regenerative Endodontics Therapy for Single-rooted Mature Permanent Tooth With Pulp Necrosis N/A
Not yet recruiting NCT03813433 - Discoloration of Endosequence and Mineral Trioxde Aggregate in Revascularization of Necrotic Immature Permanent Teeth N/A
Completed NCT03589560 - Evaluation of Biodentine and Mineral Trioxide Aggregate in Revascularization of Non Vital Immature Anterior Teeth N/A
Not yet recruiting NCT03717337 - Success Rate of Single Versus Two Visit Regenerative Treatment Protocol in Non Vital Mature Anterior Teeth N/A
Completed NCT01817413 - Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Phase 4
Completed NCT03849222 - Evaluation the Effect of Using of Apical Matrix With Apexification Procedure on Apical Healing of Necrotic Immature Teeth Phase 2/Phase 3