Pulmonary Ventilation Clinical Trial
Official title:
The Influences of Different Type of Ventilation Breathing Tube Among Children and Neonate Under General Anesthesia
To discover whether different types of ventilation breathing tube influence ventilation effect of children/ neonate, the investigators analysis tidal volume, end tidal carbon dioxide, compliance among children and neonate under general anesthesia. The study compares eight ventilator breathing tube of different length, diameter, material of the ventilator breathing tube. Besides, the investigators also make an approach verify the change of body temperate under different gas flow(2L, and 5L).
In previous research, initial mechanical ventilator settings about children were as
following: 1.tidal volume 6 to 10 ml/kg of ideal body weight; 2.delta pressures of
respiratory pressure should be <10 cmH2O in healthy patients; 3. respiratory pressures could
be kept less than 28 to 30 cmH2O in patient with lung injury; 4. positive end-expiratory
pressure was necessary, although the optimal level is unknown.
However, few researches discussed about Influences of different types of ventilation
breathing tube. The investigators want to clarify the character about length, diameter, and
material of the ventilation breathing tube under the ventilation system in relation to tidal
volume, end tidal carbon dioxide, compliance among children and neonate.
During this study, the participants will be 100 children who were ASA class1, 2 and performed
non-emergency, non-cardiac surgery, who will receive general anesthesia . The participants
will divide into three groups according to different body weights (Group N: <4.5kg; Group T:
4.5~20kg; Group C: >20kg), and would receipt total eight type of ventilator breathing tube
test. Primary outcome will be the difference of tidal volume, end tidal carbon dioxide and
compliance. Besides, secondary outcome will be the change of body temperate under different
gas flow (2L, and 5L).
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