Clinical Trials Logo
  1. Home
  2. Pulmonary Ventilation
  3. NCT02864017

Immuno Nutrition by L-citrulline for Critically Ill Patients — Immunocitre  

Intubation Clinical Trial

Official title:
Immuno Nutrition by L-citrulline for Critically Ill Patients

Clinical Trial Summary

The main objective of this study is to demonstrate that the only administration of L-citrulline, can improve immune functions in critically ill patients at high risk of nosocomial infection.

Clinical Trial Description

This is a multicentric therapeutic trial, randomized and double blind: standard enteral nutrition plus L-citrulline (5 grams/12 Hours for 5 days from the admission in Intensive Care Unit (ICU)) versus standard enteral nutrition plus placebo.

Methods-Patients: Non-surgical patients admitted in medical intensive care unit, under mechanical ventilation for an expected duration > 2 days, without severe sepsis or septic shock, will be enrolled. Symptoms leading for ICU admission ongoing for five days maximum. On admission (before treatment), the severity will be evaluated with the Sepsis-related Organ Failure Assessment (SOFA) score together with an assessment of plasmatic arginine, cytokines (InterLeukin-6 (IL6) ), and expression of Human Leukocyte Antigen - antigen D Related (HLA-DR) by monocytes. The same evaluation will be repeated on day 3 (during treatment) and on day 7 (after treatment).

The enrolment of 100 patients is statistically enough to demonstrate a decreased SOFA scores in the L-citrulline group as compared to the placebo group on day 7. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02864017
Study type Interventional
Source Rennes University Hospital
Contact
Status Completed
Phase N/A
Start date September 2016
Completion date April 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT03277872 - NoL, HR and MABP Responses to Tracheal Intubation Performed With MAC Blade Versus Glidescope N/A
Suspended NCT04253795 - Nonintubated Versus Intubated Anesthesia in Video-assisted Thoracic Surgery N/A
Completed NCT02900807 - CT-scan Airways Mensuration - Correlation to External Measurements
Completed NCT01823328 - Ketamine Versus Etomidate for Rapid Sequence Intubation Phase 4
Completed NCT02350933 - Endoscopic Evaluation of the Paediatric Airway After Prior Prolonged (>24 h) Tracheal Intubation N/A
Completed NCT01170455 - Nasal Intubation Using the Blind Intubation Device N/A
Completed NCT00980590 - Airway Scope and Macintosh Laryngoscope for Tracheal Intubation in Patients Lying on the Ground N/A
Completed NCT05515107 - The Laryngoscopic View With C-MAC Videolaryngoscope Miller Blade Lifting the Epiglottis or the Vallecula in Children N/A
Completed NCT06249659 - Impact of Extubation Location After Surgery on Perioperative Times
Completed NCT03677505 - KoMAC Videolaryngoscope for Double-lumen Intubation N/A
Completed NCT03328182 - Assessment of an Oral Endotracheal Subglottic Tube Holder N/A
Recruiting NCT02277405 - Pediatric Intubation During Resuscitation N/A
Recruiting NCT02277652 - Endotracheal Intubation Devices N/A
Recruiting NCT02073786 - Rigid Video Stylet Vs Conventional Lightwand Intubation N/A
Completed NCT02277418 - Venner a.p. Advance Video Laryngoscope N/A
Completed NCT01003327 - Comparison of the I-gel Laryngeal Mask and the Classic Laryngeal Mask in Patients With a BMI>25 Phase 4
Completed NCT00956592 - Clinical Evaluation of the Storz CMAC Laryngoscope N/A
Completed NCT00783731 - Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED) N/A
Recruiting NCT03887897 - First Attempt Intubation Rate With Airtraq vs Macintosh Direct Laryngoscope N/A
Completed NCT02931019 - The Effect of Head Position on the Intubating Condition Using Fiberoptic Bronchoscopy N/A