Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to compare peoples with disease (sarcoidosis) to those without disease. We want to see if people with sarcoidosis have a different immune response to those people without disease. The goal of this study is to see if the nicotine patch is an anti-inflammatory treatment for sarcoidosis.


Clinical Trial Description

Until recently, there was no good explanation for the fact that smoking cigarettes actually reduces the risk of sarcoidosis. Research studies have shown that the nicotine, a common component of cigarette smoke, strongly suppresses the immune system and reduces the type of inflammation that is characteristic of sarcoidosis in the lungs. We propose that nicotine treatment, administered in the form of a skin patch, will reduce the severity of lung disease in patients with sarcoidosis. Sarcoidosis patients who volunteer to participate in this study will submit standardized questionnaires relating to their quality of life and the severity of their shortness of breath before and after treatment. We will also compare objective measures of lung function, radiographic parameters, and the severity of lung inflammation. We predict that nicotine treatment will reduce the severity of sarcoidosis symptoms, improve lung function, and resolve lung inflammation. If our hypothesis is proven to be correct in this relatively small group of patients, we will perform additional studies in a larger group of patients and will consider the features of sarcoidosis patients that predict a favorable response to nicotine and other nicotine-like drugs. If nicotine is ultimately found to be an effective treatment for sarcoidosis, it may replace some of the existing treatments which are frequently ineffective and have unacceptable side-effects. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00701207
Study type Interventional
Source Ohio State University
Contact
Status Completed
Phase Early Phase 1
Start date July 2008
Completion date December 31, 2010

See also
  Status Clinical Trial Phase
Completed NCT04064242 - Study of Efficacy, Safety and Tolerability of CMK389 in Patients With Chronic Pulmonary Sarcoidosis Phase 2
Terminated NCT00262132 - Mycophenolate for Pulmonary Sarcoidosis Phase 3
Recruiting NCT05415137 - Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis Phase 3
Recruiting NCT00001532 - Role of Genetic Factors in the Development of Lung Disease
Completed NCT04318392 - Breath Analysis in Patients With Suspected Sarcoidosis: The VOCs-IS Study
Active, not recruiting NCT03755245 - Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis N/A
Completed NCT01587001 - The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis N/A
Recruiting NCT05890729 - A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis Phase 1/Phase 2
Recruiting NCT02824419 - Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis Phase 2/Phase 3
Recruiting NCT06205121 - Efficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis Phase 2
Completed NCT02200146 - Hydroxychloroquine as Steroid-Sparing Agent in Pulmonary Sarcoidosis (HySSAS). Phase 3
Terminated NCT01732211 - A Phase 2, Safety, Tolerability, and Efficacy Study of PD 0360324 in Chronic Pulmonary Sarcoidosis Phase 2
Enrolling by invitation NCT06169397 - An Open-label Extension Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis Phase 2
Active, not recruiting NCT05368883 - Comparison of the Effects of One-Legged and Two-Legged Exercise Training on Exercise Capacity and Fatigue in Patients With Sarcoidosis N/A
Not yet recruiting NCT05247554 - Randomized Controlled Trial of Hydroxychloroquine Combined With Low-dose Corticosteroid in Pulmonary Sarcoidosis Phase 3
Completed NCT03599414 - CASPA: CArdiac Sarcoidosis in PApworth
Recruiting NCT02188017 - Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS) Phase 4
Recruiting NCT06113991 - Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis
Completed NCT01169038 - Investigation of the Efficacy of Antibiotics on Pulmonary Sarcoidosis Phase 1
Completed NCT03824392 - Study of Intravenous ATYR1923 (Efzofitimod) for Pulmonary Sarcoidosis Phase 1/Phase 2