Pulmonary Nodule Clinical Trial
Official title:
Does Ultra Short-term Steroid Therapy Increase the Accuracy of FDG-PET/CT in Evaluation of Pulmonary Nodules?
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before
and after steroid therapy may help doctors assess a patient's response to treatment and help
plan the best treatment.
PURPOSE: This phase I trial is studying fludeoxyglucose F 18 PET scan performed before and
after ultra short-term dexamethasone therapy to see how well it measures changes in nodules
in patients with lung nodules.
OBJECTIVES:
- To determine whether ultra short-term steroid therapy (24-48 hours) can be used to
increase the accuracy of fludeoxyglucose F 18 positron emission tomography/computed
tomography (FDG-PET/CT) imaging in categorizing nodules in patients with pulmonary
nodules.
- To calculate the overall sensitivity and specificity of the nodules group, based on FDG
uptake, for predicting malignancy.
- To gather effect-size estimates that will be used to improve the quality of a larger
follow-up study.
OUTLINE: Patients receive oral dexamethasone at 40, 28, 16, and 4 hours before imaging.
Patients undergo fludeoxyglucose F 18 (FDG)-positron emission tomography/computed tomography
(PET/CT) imaging at baseline and upon completion of steroid therapy.
After completion of study therapy, patients are followed for 6 months.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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