Clinical Trials Logo

Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

Filter by:

NCT ID: NCT01241942 Terminated - Cystic Fibrosis Clinical Trials

Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability

Start date: December 2010
Phase: N/A
Study type: Interventional

The purpose of this research study is to perfect the technique of EVLP and learn about the safety of transplanting lungs that have been ventilated (attached to a breathing machine or ventilator to deliver oxygen) and perfused with a lung perfusion solution (Steen solution™, made by Vitrolife). This ventilation and perfusion will be done outside the body (ex-vivo) in a modified cardiopulmonary bypass circuit (the kind of device used routinely during most heart surgeries). The purpose of performing ex-vivo lung perfusion and ventilation (EVLP) is to learn how well the lungs work, and whether they are likely safe to transplant.

NCT ID: NCT01220908 Completed - Emphysema Clinical Trials

Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema

Start date: January 2008
Phase: N/A
Study type: Interventional

The objective of this study is to demonstrate the safety of the PneumRx Lung Volume Reduction Coil (LVRC) in a population of patients with emphysema. The PneumRx, Inc. LVRC is a used as a less invasive alternative to lung volume reduction surgery. The PneumRx LVRC is designed as an alternative to lung volume reduction surgery, potentially achieving the desired reduction in lung volume limiting the risks associated with major surgery, such as illness or death. This device is deployed through a bronchoscope and requires no incision.

NCT ID: NCT01217671 Completed - Emphysema Clinical Trials

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Start date: December 2009
Phase: Phase 2/Phase 3
Study type: Interventional

This is a randomised , placebo controlled, double blind , multicentre, Phase II/III study evaluating the safety and efficacy of Kamada AAT for inhalation in patients with Emphysema caused by Alpha-1 Antitrypsin (AAT) deficiency.

NCT ID: NCT01192932 Completed - COPD Clinical Trials

Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)

Start date: March 2010
Phase: N/A
Study type: Observational

Computed tomography (CT) studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) have never considered nycthemeral variations. Airway calibre, in COPD patients, exhibits a nycthemeral variations with maximal values around noon and minimal values in the early morning, that persists under long-acting bronchodilator. Furthermore, no study has assessed the possible nycthemeral variations of CT scans parameters reflecting airway remodelling and emphysema extent in COPD patients. This is a prospective study whose purpose is to assess these variations and their relationships with pulmonary function testing (PFT) in COPD patients.

NCT ID: NCT01181466 Completed - COPD Clinical Trials

AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema

Start date: August 2010
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to assess the procedural and post-procedural safety and efficacy of AeriSeal therapy at up to 4 subsegments during a single treatment session in patients with GOLD Stage III/IV homogeneous or heterogeneous emphysema.

NCT ID: NCT01142531 Completed - COPD Clinical Trials

Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent.

Start date: March 2010
Phase: N/A
Study type: Observational

CT studies considering bronchial dimensions in chronic obstructive pulmonary disease (COPD) were conducted without control of bronchodilation. Some data however suggest that total lung capacity (CT scan is performed after full inspiration) is increased in individuals affected by chronic or spontaneous bronchoconstriction and may decrease after bronchodilatation. Furthermore, no study has assessed the effect of bronchodilation on CT scans parameters reflecting airway remodelling and emphysema extent in COPD patients. This is a prospective study whose purpose is to assess the effect of bronchodilation on lung CT scan and pulmonary function testing (PFT) in COPD patients.

NCT ID: NCT01121367 Completed - Emphysema Clinical Trials

Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema

Start date: May 2010
Phase: N/A
Study type: Observational

This study is to evaluate the expression of biological markers in induced sputum and peripheral blood T lymphocytes of patients with combined pulmonary fibrosis and emphysema (CPFE). The features of CPFE would be observed, including pulmonary function tests and fractional exhaled nitric oxide (FENO).

NCT ID: NCT01110252 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease

COPD-01
Start date: May 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the cell therapy with bone marrow mononuclear cells is safe in the treatment of chronic obstructive pulmonary disease, specifically the pulmonary emphysema.

NCT ID: NCT01102712 Completed - Clinical trials for Chronic Obstructive Pulmonary Disease

Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction

BTVA
Start date: November 2009
Phase: N/A
Study type: Interventional

To establish and confirm the safety and clinical utility of BTVA applied unilaterally for lung volume reduction in patients with upper lobe predominate heterogeneous severe emphysema.

NCT ID: NCT01051258 Completed - Lung Diseases Clinical Trials

AeriSeal System for Lung Volume Reduction

Start date: November 2009
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of AeriSeal treatment in patients with advanced emphysema.