Pulmonary Embolus/Emboli Clinical Trial
Official title:
Venous Phade Dual Energy Computed Tomography in Patients Suspected for Pulmonary Embolism: Diagnostic Accuracy and Evaluation of Incidental Findings.
Venous phase spectral or dual energy (DE) chest computed tomography (CT) in patients with suspected pulmonary embolism (PE) compared to standard computed tomography pulmonary angiography (CTPA): sensitivity, evaluation of iodine mapping and incidental findings.
Status | Recruiting |
Enrollment | 160 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: - Patients suspected for pulmonary embolism undergoing a computed tomography pulmonary angiography - Minimum age 50 years Exclusion Criteria: - Temporarily or permanently incompetent patient not able to give informed consent - No informed consent obtained for other reasons - Allergic to iodine based contrast media - Impaired renal function - Patients with thyreotoxicosis - Non-diagnostic quality of computed tomography images |
Country | Name | City | State |
---|---|---|---|
Denmark | Copenhagen University Gentofte Hospital | Copenhagen | Hellerup |
Denmark | Copenhagen University Hospital, Herlev Hospital | Copenhagen | Herlev |
Lead Sponsor | Collaborator |
---|---|
Copenhagen University Hospital at Herlev |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sensitivity | Per patient sensitivity of portal venous phase chest DECT in diagnosing PE compared to the corresponding reference CTPA | through study completion, approx. of 1 year | |
Primary | Specificity | Per patient specificity of portal venous phase chest DECT in diagnosing PE compared to the corresponding reference CTPA | through study completion, approx. 1 year | |
Secondary | Sensitivity | Lobe and segment based sensitivity of portal venous phase chest DECT in diagnosing PE compared to the corresponding reference CTPA | through study completion, approx. of 1 year | |
Secondary | Specificity | Lobe and segment based specificicty of portal venous phase chest DECT in diagnosing PE compared to the corresponding reference CTPA | through study completion, approx. of 1 year | |
Secondary | Incidental findings | Evaluation and management of incidental findings in portal venous phase chest CT compared to standard care CTPA. | through study completion, approx. of 1 year | |
Secondary | Iodine mapping | Comparison of perfusion defects on iodine mapping between portal venous chest CT and CTPA. Descriptive. | through study completion, approx. of 1 year |
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