Strategies to Reduce Contrast Medium in Spectral CT Pulmonary Angiography

Status Completed

Clinical Trial Summary

The purpose of this study is to assess the effect of three different strategies to inject at reduced volume of contrast medium in Computed Tomography Pulmonary Angiography (CTPA). 330 patients referred for CTPA are randomized to receive either a low-concentration, a low-volume or a saline-diluted injection. Effects on the level and homogeneity of contrast enhancement are measured and compared between groups.

Clinical Trial Description

Spectral detector CT facilitates large reductions in contrast medium in vascular CT examinations. To our knowledge, no studies have so far compared different strategies to inject this reduced contrast dose. The purpose of this study is to assess the effect of three different strategies to inject at reduced volume of contrast medium in Computed Tomography Pulmonary Angiography (CTPA). 330 patients referred for clinically indicated CTPA are randomized to receive either a low-concentration, a low-volume or a saline-diluted injection. All patients receive the same amount of iodine (140 mg/kg). Effects on the level and homogeneity of contrast enhancement, image noise, contrast-to-noise-ratio and signal-to-noise-ratio are measured in the CT images and the results are compared between groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05592444
Study type	Interventional
Source	University Hospital, Akershus
Contact
Status	Completed
Phase	N/A
Start date	November 23, 2020
Completion date	October 12, 2021

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