Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection

Pulmonary Embolism Clinical Trial

Official title:

Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04251247
• Other study ID #: 2020/514/169/B
• Status: Recruiting
• Start date: March 1, 2020
• Est. completion date: January 31, 2025

Study information

• Verified date: March 2024
• Source: Dr. Lutfi Kirdar Kartal Training and Research Hospital
• Contact: Avni Uygar Seyhan, M.D.
• Phone: 902164583000
• Email: uygarseyhan[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute aortic dissection is rare but potentially life-threatening disease with an incidence of 5-30 cases per million, annually. Therefore prompt diagnosis is crucial. D-dimer values have been shown to be useful in the diagnosis of acute aortic dissection. Fibrinogen levels have been shown to be low, normal or high in individuals with acute aortic dissection. This study aims to investigate whether D-dimer/fibrinogen ratio can be valuable for diagnosis of acute aortic dissection.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 159
• Est. completion date: January 31, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Diagnosis of acute aortic dissection

• Diagnosis of acute pulmonary embolism

• Diagnosis of non-cardiac chest pain

Exclusion Criteria:

• Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain

• Participants who do not give consent for enrollment

Related Conditions & MeSH terms

• Aortic Dissection
• Embolism
• Pulmonary Embolism

Intervention

Diagnostic Test:
• D-dimer/fibrinogen ratio
The ratio of D-dimer (ng/ml) to fibrinogen (mg/dl)

Locations

Country	Name	City	State
Turkey	Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital	Istanbul
Turkey	Kartal Dr. Lutfi Kirdar Training and Research Hospital	Istanbul

Sponsors (1)

Lead Sponsor	Collaborator
Dr. Lutfi Kirdar Kartal Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (4)

Eggebrecht H, Naber CK, Bruch C, Kroger K, von Birgelen C, Schmermund A, Wichert M, Bartel T, Mann K, Erbel R. Value of plasma fibrin D-dimers for detection of acute aortic dissection. J Am Coll Cardiol. 2004 Aug 18;44(4):804-9. doi: 10.1016/j.jacc.2004.04.053. — View Citation

Guan XL, Wang XL, Liu YY, Lan F, Gong M, Li HY, Liu O, Jiang WJ, Liu YM, Zhu JM, Sun LZ, Zhang HJ. Changes in the Hemostatic System of Patients With Acute Aortic Dissection Undergoing Aortic Arch Surgery. Ann Thorac Surg. 2016 Mar;101(3):945-51. doi: 10.1016/j.athoracsur.2015.08.047. Epub 2015 Oct 23. — View Citation

Hajsadeghi S, Kerman SR, Khojandi M, Vaferi H, Ramezani R, Jourshari NM, Mousavi SA, Pouraliakbar H. Accuracy of D-dimer:fibrinogen ratio to diagnose pulmonary thromboembolism in patients admitted to intensive care units. Cardiovasc J Afr. 2012 Sep;23(8):446-56. doi: 10.5830/CVJA-2012-041. — View Citation

Kara H, Bayir A, Degirmenci S, Kayis SA, Akinci M, Ak A, Celik B, Dogru A, Ozturk B. D-dimer and D-dimer/fibrinogen ratio in predicting pulmonary embolism in patients evaluated in a hospital emergency department. Acta Clin Belg. 2014 Aug;69(4):240-5. doi: 10.1179/2295333714Y.0000000029. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute aortic dissection	Diagnosis of acute aortic dissection confirmed by contrast enhanced computed tomography, magnetic resonance imaging, echocardiography or aortography	24 hours