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Exploratory Metabolomics Study of Exhaled Breath in Pulmonary Embolism — MetabolAir  

Pulmonary Embolism Clinical Trial

Official title:
Exploratory Metabolomics Study of Exhaled Breath in Pulmonary Embolism

Clinical Trial Summary

Pulmonary embolism is a frequent and recurrent pathology, especially in the elderly. It is often preventable, with high mortality and morbidity, making it a major public health issue. The clinical presentation of pulmonary embolism is non-specific and very highly variable, ranging from asymptomatic thrombus diagnosed incidentally to sudden death. The current diagnosis of pulmonary embolism is based on several diagnostic techniques, mainly non-invasive, which should be used sequentially. We propose to sample the volatile organic compounds using a device that allows them to be trapped on polymer cartridges. Sampling will be performed under monitoring of respiratory pressure and a capnograph to collect alveolar and upper respiratory tract air separately without contamination of the oral cavity or sinuses. This exploratory metabolic analysis will be non-targeted (analysis of all molecules detectable without a priori). The main objective of the study is to identify specific metabolic profiles to predict the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism. Secondary purposes : - To identify metabolic profiles to be used to predict, in combination with clinical probability scores, the results of ventilation-perfusion pulmonary tomoscintigraphy in subjects undergoing this examination for suspected acute pulmonary embolism.; - To correlate metabolic profiles with the topography of embolized lung territories

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04001179
Study type Observational
Source University Hospital, Strasbourg, France
Contact Arnaud Agin, PhD
Phone 03.88.12.88.56
Email arnaud.agin@chru-strasbourg.fr
Status Recruiting
Phase
Start date December 1, 2021
Completion date December 1, 2023
View Details
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