Effects of Standing at Different Angles on Transpulmonary Pressure

Pulmonary Disease Clinical Trial

Official title:

Effects of Standing at Different Angles on Transpulmonary Pressure

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04451421
• Other study ID #: transpulmonary pressure
• Status: Not yet recruiting
• Phase: N/A
• Start date: October 1, 2020
• Est. completion date: October 1, 2021

Study information

• Verified date: June 2020
• Source: Chinese PLA General Hospital
• Contact: Zhao Ying
• Phone: 17600953801
• Email: 1412888703[@]qq.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Effects of standing at different angles on transpulmonary pressure

Description:

Objective: To study the effect of different standing angles on cross-lung pressure.Background: Long-term bed rest in ICU patients leads to upward movement of diaphragm and increased intrathoracic pressure in mechanically ventilated patients, resulting in lower cross-lung pressure. If the end-expiratory cross-lung pressure is negative, lung tissue compression and atelectasis will occur.Standing can lower the diaphragm, improve the pressure across the lungs, and improve ventilation.Selection methods: patients with invasive mechanical ventilation in the ICU, on the premise of stable hemodynamics, with the aid of electric bed training in standing in different angles, start from 20 degrees, 5 degrees up every five minutes, the largest up to 80 degrees, each Angle across the pulmonary pressure, die cavity ratio, tidal volume and breathe out carbon dioxide at the end of the record, and record whether low blood pressure, an accident in the process of take off the tube and other adverse reactions.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: October 1, 2021
• Est. primary completion date: October 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 95 Years

Eligibility

Inclusion Criteria:

• The age is = 18 years old;

• the hemodynamics is stable;

• 50 < heart rate < 120 beats / min ;

• 90 < systolic blood pressure < 200mmHg ;

• 55 < mean arterial pressure < 120mmHg;

• do not increase the dose of pressor drugs for at least 2 hours;

• intracranial pressure is stable and there are no seizures within 24 hours;

• the respiratory state is stable;

• the patient's finger pulse oxygen saturation = 88%;

• 10 < respiratory frequency < 35 beats / min.

Exclusion Criteria:

• Pregnancy;

• acute cardio-cerebrovascular events;

• spinal or limb fractures;

• active bleeding.

Related Conditions & MeSH terms

• Lung Diseases
• Pulmonary Disease

Intervention

Behavioral:
• Change of standing Angle
Change the patient's standing Angle by using an electric bed

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Chinese PLA General Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	transpulmonary pressure	End-expiratory pressure across the lungs is recommended at 0-5cmH2O.	5 minutes
Primary	Esophageal pressure	The change in esophageal pressure represents the degree of inspiratory effort.The greater the variation, the harder the inhale.	5 minutes
Primary	Dead space rate	the smaller,the better	5 minutes
Primary	tidal volume	Standard tidal volume: standard weight based on height, 6 to 8ml per kg body weight	5 minutes
Primary	partial pressure of carbon dioxide in endexpiratory gas	The smaller the difference between pCO2 and arterial blood gas, the better	5 minutes
Secondary	adverse reaction	hypotension?Accident to take off the tube?Drop of bed,Record the number of times it happens.The more it happens, the less safe it is.	an hour