Pulmonary Atelectasis Clinical Trial
Official title:
Atelectasis After Pulmonary Lobectomy: The Effect Of Air During One-Lung Ventilation (OLV) On Postoperative Atelectasis.
Patients scheduled for lung lobe resection using video assisted thoracic surgery will be
randomly assigned to be ventilated with either only oxygen or a mixture of air and oxygen.
The primary purpose of this study is to determine if the incidence of postoperative collapse
(in the non-surgical lung) is decreased when using a mixture of air and oxygen compared to
using only oxygen (which is our control measurement) during one-lung ventilation.
One of the concerns with all thoracic procedures employing One Lung Ventilation (OLV) is
intra-operative hypoxia due to the large shunt that develops when only one lung is being
ventilated. Ventilation with a higher fraction of inspired oxygen (FIO2) is one of the
commonly chosen strategies for the treatment of hypoxemia during (OLV) for thoracic surgery.
Using an FIO2 of 1.0 at all times during (OLV), however, may increase the risk of absorption
atelectasis intra and postoperatively which itself leads to persistent hypoxia and
potentially pneumonia.
The aim of this study is therefore to determine the impact of adding air to the inspired
fraction of oxygen during (OLV) primarily on the incidence of postoperative atelectasis of
the nonsurgical lung after lung resection using video assisted thoracic surgery and
secondarily on intraoperative and postoperative oxygenation.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
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