Pulmonary Aspiration Clinical Trial
Official title:
Mitigating Harm: Assessing Preoperative Residual Gastric Volumes to Risk Stratify Patients Administering Semaglutide
Given the pharmacodynamic and pharmacokinetic properties of glucagon-like peptide-1 (GLP-1) agonists, the Canadian Anesthesiologists' Society has recognized that patients on GLP-1 agonists may have an increased aspiration risk due to a 'full stomach,' even after following preoperative fasting guidelines. In other words, safe fasting timelines are not known in individuals taking GLP-1 agonists, as demonstrated by recent case reports of patients who either retained or regurgitated stomach contents despite being adequately fasted. To address this gap, we plan to measure preoperative residual gastric volumes with point-of-care ultrasound (POCUS) in patients taking this medication. The priority is to first gather data to identify which patient populations need risk stratification and to then use this data to support the development of specific guidelines that reduce anesthetic complications, such as aspiration pneumonia. Our primary objective is to use POCUS preoperatively to assess gastric volumes of fasted patients to demonstrate if there is a clinically significant increase in residual gastric volumes in patients on semaglutide.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05637918 -
Ultrasound for Prediction of Empty Stomach in Infants
|
||
| Not yet recruiting |
NCT06303492 -
Aspiration Risk Assessment by Gastric Ultrasound in eMErgency Surgery and ANesThetic Decision-making: The ARGUMENT Study
|
N/A | |
| Completed |
NCT01833676 -
To Compare Effect of Sevoflurane Versus Desflurane on the Return of Swallowing Reflexes in the Elderly
|
Phase 4 | |
| Completed |
NCT05889637 -
Gastric Ultrasound Assessment for Preoperative Prandial State of Patients Taking Glucagon-Like Peptide-1 Receptor Agonists
|
||
| Completed |
NCT05959135 -
Gastric Ultrasound in Diabetic and Non-Diabetic Pregnant Women
|
||
| Completed |
NCT04106635 -
Effect of Paratracheal Esophagus Pressure on the Insertion of Laryngeal Mask Airway
|
N/A |