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Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAH — REPEAT-PAH  

Pulmonary Artery Hypertension Clinical Trial

Official title:
Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAH (REPEAT-PAH)

Clinical Trial Summary

The purpose of this study is to examine N-terminal pro brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) biomarkers in a number of different settings including assessing the repeatability of laboratory and point of care testing (POCT), the effect of a time delay and exercise have on laboratory measurements. Also to compare the clinical and analytical performances of NT-proBNP and BNP POCT samples across the spectrum of disease severity and finally assess whether POCT in PAH can detect change in patients commencing or escalating PAH treatment.

Clinical Trial Description

- Patients that are attending clinical appointments will be approached to ask if they will take part in the study. - Patients will be assessed at two separate visits. - Patients will be randomised to either exercise or rest group on their 1st visit. On the 2nd visit patients will be asked to participate in the alternate group to what they completed on their previous visit. - At each visit they will have 2 blood samples taken, at time point 1 and at time point 2 (T1 and T2). These will be taken at least one hour apart, each with a period of at least 15 mins rest in the sitting position prior to sampling. - On one of these two visits the patient will undergo exercise testing between T1 and T2. - In addition, a further laboratory testing tube will be taken for a delayed NT-proBNP. This will be subjected to gentle agitation (laboratory rotator) for 48 hours prior to processing to simulate, in a controlled environment, the effect of transport and delay on sample measurement. - Retrospectively information will be collected regarding the patient's disease severity and any change to treatment that occurred between the two visits. - A total of 40 patients with be sampled with an interim analysis after 20 patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05421949
Study type Observational
Source Sheffield Teaching Hospitals NHS Foundation Trust
Contact
Status Completed
Phase
Start date February 19, 2021
Completion date August 30, 2022
View Details
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