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Prospective Trial of Rituximab for Primary Pulmonary Alveolar Proteinosis — PAP  

Pulmonary Alveolar Proteinosis Clinical Trial

Official title:
Prospective Open-Label Trial of Rituximab for Primary Pulmonary Alveolar Proteinosis

Clinical Trial Summary

The purpose of this study is to determine whether the use of rituximab is effective in treating pulmonary alveolar proteinosis by leading to an improvement in lung function and disease status.

Clinical Trial Description

The goal of this study is to conduct a prospective, open-label 6-month trial of rituximab in patients who present with symptomatic primary or idiopathic PAP. A total of 10 subjects with primary PAP will be enrolled over 12 months at East Carolina University. Patients over age 18 with a clinical diagnosis of moderate symptomatic idiopathic PAP, established by appropriate clinical history, radiographic and physiologic findings, presence of circulating anti-GM-CSF antibody, and confirmatory findings on bronchoscopy with bronchoalveolar lavage and/or open-lung biopsy will be recruited. Patients with newly diagnosed PAP or established disease may be considered for this study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00552461
Study type Interventional
Source East Carolina University
Contact
Status Completed
Phase Phase 2
Start date January 2007
Completion date December 2011
View Details
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