Efficacy of Autologous Fibrin Glue in Pterygium

Status Completed

Clinical Trial Summary

Pterygium is wing-shaped, vascular, fleshy growth that originates on the conjuntiva and that can spread to the corneal limbus and beyond The surgical exeresis with autologous conjunctival autograft technique is the treatment of choice. Commercially available fibrin glue has been used preferentially for graft fixation due to its benefits compared to sutures; However, its cost and the risk of inflammatory immune reaction limit the its use. There are few studies about autologous fibrin glue. OBJECTIVE: To determine the efficacy of autologous fibrin glue preparation in patients undergoing pterygium resection surgery. To compare with autologous conjunctival graft fixation with suture. This is a randomized clinical trial. Two patient groups will undergo pterygium excision surgery. Group 1 will have autologous conjunctival graft fixation with autologous fibrin glue and group 2 will have suture graft fixation using 10.0 mononylon. Early and late postoperative surgical results as well as complication rates will be analyzed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Pterygium

Clinical Trial Details

NCT number	NCT04151017
Study type	Interventional
Source	Hospital de Clinicas de Porto Alegre
Contact
Status	Completed
Phase	N/A
Start date	June 12, 2019
Completion date	December 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT02641132` - Pterygium Head Body MMC1: Two Different Surgical Procedures and Their Effect on Endothelial Cell Count.	Phase 4
Completed	`NCT02342392` - Intralesional Ranibizumab on Pterygium Vascularity, Size and Recurrence Rate: a Pilot Study	Phase 2/Phase 3
Recruiting	`NCT01387971` - Using Impression Cytology to Observe the Cytological Changes of Ocular Surface Cells in Various Ocular Surface Disorders	N/A
Recruiting	`NCT05978687` - The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision	Phase 4
Not yet recruiting	`NCT06042296` - Expression of CD44, PCNA and E-cadherin in Pterygium Tissue
Completed	`NCT04022811` - Effect of Bromfenac on Pain Related to Pterygium Surgery	Phase 4
Recruiting	`NCT01249235` - Bandage Contact Lens and Oral Analgesics Versus Patching and Oral Analgesics for Pain Following Pterygium Surgery	N/A
Recruiting	`NCT01261455` - Prospective Randomized Pilot Study Comparing Inferior Versus Superior Conjunctival Autografts for Primary Pterygia	N/A
Completed	`NCT01115517` - Safety Study of Avastin Used as Adjunctive Therapy in Pterygium Surgery	Phase 2
Completed	`NCT00768963` - Ranibizumab for the Inhibition of Neovascularization in Pterygia	Phase 1
Completed	`NCT00949728` - Conjunctival Autologous Transplantation Using Fibrin Glue in Primary Pterygia	N/A
Recruiting	`NCT00563277` - Surgical Treatment of Concurrent Cataract and Primary Pterygium	N/A
Completed	`NCT00346450` - Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation	Phase 3
Completed	`NCT03533244` - A Study of the Response to AG-86893 in Patients With Pterygium Hyperemia	Phase 2
Completed	`NCT04403516` - Dextenza in Pterygium Surgery	Phase 4
Recruiting	`NCT02911532` - Tissue Engineering Conjunctiva for the Treatment of Pterygium and Atretoblepharia	N/A
Not yet recruiting	`NCT03304366` - Corneal Changes With Pentacam Before and After Pterygium	N/A
Unknown status	`NCT02015000` - Surgical Result of Pterygium Extended Removal Followed by Fibrin Glue Assisted Amniotic Membrane Transplantation	N/A
Completed	`NCT00344201` - Assessment of Fibrin Glue in Pterygium Surgery and Other Forms of External Eye Surgery	Phase 1
Recruiting	`NCT00326560` - Comparison of Glue With Sutures for Pterygium Surgery	Phase 3